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英国exeter大学 博后招聘
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隆重推荐该博后职位，5月10日截止，有意者速速联系啊。 Research Post-Doctoral Assistant in biophysical and molecular characterisation of ER-organelle interactions in plants. Post-Doctoral Research position Fixed Term Contract for 3 years The College wishes to recruit a full-time Post- Doctoral Research Assistant to participate in a Leverhulme Trust funded project on biophysical and molecular characterisation of ER-organelle interactions in plants. This full-time, three year post is available from1st October 2015 (or earlier if possible) in the College of Life and Environmental Sciences. The post-holder will work in the laboratory of Dr Imogen Sparkes based in Biosciences at the Exeter campus. Organelle dynamics in highly vacuolated plant epidermal cells appears erratic, yet defects in the molecular drivers (myosins) affect growth, development and response to external stimuli. The endoplasmic reticulum (ER) pervades the cortex of the cell and appears intimately associated with several organelles (Sparkes et al. Curr Opin Plant Biol. 2011 14:658-65; Sparkes Mol. Plant 2011 4:805-12). Here, we will determine if organelles are attached, and isolate and characterise the molecular components involved in tethering organelles to the ER in Arabidopsis. This could have profound implications on 'communication' within the cell. The post will include construction of expression vectors for plant-cell transformation, live cell imaging (eg confocal / spinning disc microscopy), analysis of organelle dynamics using software such as Imaris and ImageJ, isolating and characterising novel tethering components. This project will entail periods of work off site with Dr. Andy Ward at the Central Laser Facility (Oxfordshire) to carry out optical tweezer work. This powerful technique will allow us to probe for direct physical interactions between organelles and the ER (Sparkes et al.Traffic 2009 10:567-71). The successful candidate will be expected to carry outwork with both Dr Sparkes and Dr Ward, and also act as part of a larger interdisciplinary team with Prof Ashwin. The Leverhulme Trust funded project also includes funding for one other post-doctoral assistant who will work with Prof Ashwin and Dr Sparkes on the biophysical aspects of ER-organelle interactions (Lin et al. Biophys. J. 2014 107:763-72). Therefore, the successful candidate must have excellent communication skills to convey complex datasets to an interdisciplinary audience. We are particularly seeking a candidate with experience in cell and molecular biology and laser microscopy (such as confocal / spinning disc). Experience with monitoring organelle dynamics would be beneficial. To view the Job Description and Person Specification document please click here. For further information please contact Dr Imogen Sparkes, e-mail I.Sparkes@exeter.ac.uk or telephone 01392 723454. We welcome applications from candidates interested in working part-time hours or job-sharing arrangements. Interviews are expected to take place on 11-12th June 2015. The College is working towards department Silver Athena SWAN awards as a commitment to providing equality of opportunity and advancing the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine. The University of Exeter is an equal opportunity employer which is 'Positive about Disabled People'. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented in the workforce. |
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