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ygy19901025木虫 (著名写手)
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[求助]
英译汉，求翻译，生物、医学方面的
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Differentially expressed lncRNAs in PD leukocytes compared to HC. Among all the leukocyte RNA-Seq detected lncRNAs, 13 exhibited differential expression in PD patients compared to matched control volunteers (FDR,0.05). Of these, 8 exhibited disease-mediated decrease, and 5- increase. For each lncRNA, given are is ensEMBL transcript ID, log fold change in PD (pre-DBS) compared to HC, FDR and chromosomal location, as well as the average count read, and count per million (CPM) in the leukocyte sequenced libraries. The brain CPM values are given as well where detected. The predicted targeted miRNAs for the 2 PD leukocyte modified possible competitive endogenous lncRNAs (ceRNAs) - the U1 small nuclear ribonucleic particle (snRNP) spliceosome component and RP11-462G22.1 (marked with *) are: for U1 - hsa-miR-188-3p, hsa-miR-512-3p, hsa-miR-125b-5p, hsa-miR-1281, hsa-miR-5091, hsamiR-4254, hsa-miR-125a-5p, hsa-miR-4319, and for RP11-462G22.1 - hsa-miR-5093, hsa-miR-877-3p, hsa-miR-27b-5p, hsa-miR-4695-5p, hsa-miR-539-5p, hsa-miR-25-5p, hsa-miR-4730, hsa-miR-4727-3p, hsa-miR-1277-5p, hsa-miR-4307, hsa-miR-29b-2-5p, hsa-miR-3142, hsa-miR-4446-5p, hsa-miR-548t-5p, hsa-miR-3922-5p, hsa-miR-769-5p, hsa-miR-3662, hsa-miR-650, hsa-miR-139-5p, hsa-miR-4494, hsa-miR-3612. Bold: lncRNAs that were also detected as altered in RNA-Seq data from PD patients’ brain samples as compared with HC brains. #: validated by qRT-PCR in both PD leukocytes and 2 brain regions (Amygdala and Substantia Nigra) of PD and unaffected individuals (the Netherlands Brain Bank). |
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yiming_0
金虫 (正式写手)
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【答案】应助回帖
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帕金森病人白细胞中长链非编码RNA与HC相比，在所有的白细胞RNA测序检测到的长链非编码RNAs中，其中帕金森病人有13对与匹配的志愿者展现了差异表达（FDR,0.05），在这13对中8对显示出现疾病介导的减少，5对增加。对于每个长链非编码RNA，给出的是ENSEMBL转录的ID，将帕金森病人与HC进行日志倍变化的对比，进行FDR和染色体位置的对比，以及平均读取数的对比，并且在白细胞序列库中进行每百万（CPM）计数对比。检测区域的大脑CPM值也会给出。预测锁定了2个帕金森病人白细胞修改的可能竞争力内生的miRNA2。 lncRNAs（ceRNAs） - 的U1小核核糖核酸颗粒（核蛋白）剪接组件和RP11-462G22.1（标有*），分别是：为U1 - HSA-的miR-188-3p，HSA-的miR-512-3p，hsa-的miR-125B-5P，HSA-MIR-1281 HSA-MIR-5091，hsamiR-4254，HSA-MIR-125A-5P，HSA-MIR-4319，以及RP11-462G22.1 - HSA-MIR-5093， HSA-的miR-877-3p，HSA-MIR-27B-5P，HSA-MIR-4695-5p，HSA-的miR-539-5p，HSA-MIR-25-5p，HSA-MIR-4730，HSA-miR- 4727-3p，HSA-MIR-1277-5p，HSA-MIR-4307，HSA-MIR-29B-2-5p，HSA-MIR-3142，HSA-MIR-4446-5p，HSA-MIR-548吨-5P， HSA-MIR-3922-5p，HSA-的miR-769-5p，HSA-MIR-3662，HSA-MIR-650，HSA-的miR-139-5p，HSA-MIR-4494，HSA-MIR-3612。 当然，同时也会检测帕金森病人与HC大脑取样中与RMA序列资料不同的长链非编码RNA， #经对帕金森病人白细胞和受帕金森影响和未受影响个体的大脑内两区域（杏仁核和黑质）定量RT-PCR有效验证 这种东西太费劲了 |
2楼2015-04-20 21:42:49