24小时热门版块排行榜

返回列表

当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖

罗三炮

金虫 (著名写手)

应助: 118 (高中生)
金币: 671.7
散金: 30
红花: 35
帖子: 1029
在线: 193.2小时
虫号: 2373291
注册: 2013-03-24
专业: 世界民族研究

[交流] 肽类药物Modulating protein–protein interactions: the potential of peptides 已有2人参与

Chemical Communications (Cambridge, United Kingdom) (2015), 51(16), 3302-3315.

Protein–protein interactions (PPIs) have emerged as important and challenging targets in chemical biology
and medicinal chemistry. The main difficulty encountered in the discovery of small molecule modulators
derives from the large contact surfaces involved in PPIs when compared with those that participate in protein–
small molecule interactions. Because of their intrinsic features, peptides can explore larger surfaces
and therefore represent a useful alternative to modulate PPIs. The use of peptides as therapeutics has
been held back by their instability in vivo and poor cell internalization. However, more than 200 peptide
drugs and homologous compounds (proteins or antibodies) containing peptide bonds are (or have been)
on the market, and many alternatives are now available to tackle these limitations. This review will focus
on the latest progress in the field, spanning from ‘‘lead’’ identification methods to binding evaluation techniques,
through an update of the most successful examples described in the literature.

回复此楼

» 本帖附件资源列表

欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com
附件 1 : c4cc08565e.pdf

2015-04-06 20:42:51, 3.77 M

» 猜你喜欢

1楼 2015-04-06 20:43:27

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

sghio

3楼2015-04-07 16:52:18

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

查看全部 3 个回答