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重庆大学 生物 张义国教授热忱欢迎2015级优秀硕士考生调剂！
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说明：由于招生名额有限，今年张义国教授团队未招到计划人数，但因主持国家重大计划集成等项目所需，故向学校申请，刚刚获批两个名额，望考生抓紧时间联系！ 1.招生类型 硕士招生、接受调剂（2名） 2.招收学校(单位)名称 重庆大学生物工程学院 3.学制以及何种专业 三年制学术型硕士，生物学或生物医学工程 4. 调剂要求： （1）本科毕业于“985”、“211”高校； （2）2015年考生原则上总分高于我校相同专业分数线10分，单科高于3分（满分为100分），5分（满分为150分），条件优秀者可以适当放宽； 5.学校或单位地点(*必填) 重庆大学（重庆市沙坪坝区174号） 6.提供的补助待遇(选填) 按学校规定发放（实验室每月另给300－500不等） 7.导师(课题组)介绍(*必填) 研究经历： 1995年获河南医科大学医学硕士后留校即任讲师，从事单克隆抗体及抗癌疫苗制备和应用研究。1998－2003年间，于美国明尼苏达(Minnesota)大学，率先研究A类紫外线(UVA)诱导癌变与细胞信号传导网络的分子机理。之后，在英国丹迪(Dundee)大学获细胞生化的哲学博士 (PhD)，留校做CO-PI研究员, 开创了核膜转录因子Nrf1及基因调控与癌变的机制研究。2007年被选为英国皇家医学协会Fellow。曾任郑州大学生物工程系教授，现任重庆大学生物医学联合学院教授。共发表90 多项出版物，其中65篇研究论文，多数发表于生物化学(JBC, BJ)和癌症(Cancer Research，Oncogene,Carcinogenesis),及 <Sci Rep_科学报告> 等一流专业研究期刊上。被SCI他引近2000次，H-指数33分。英文简介(http://www.paper.edu.cn/index.ph ... lar/homepage/604116 ). 研究方向： 1）细胞生化和拓扑生物学； 2）癌症生物学与基因调控； 3）脂肪肝炎恶化为肝癌的分子病理学； 4）Nrf1抗老化与癌变机制及化学防治。 近期研究论文 (*corresponding author), 如下: （具体详情见http://www.paper.edu.cn/scholar/homepage/604116） Yiguo Zhang*, Yonggang Ren, Shaojun Li, John D Hayes (2014) Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains. PLoS One. 2014 Apr 2;9(4):1-17; e93458. doi: 10.1371/journal.pone.0093458. Michelle A Schultz, Sharika S Hagan, Amrita Datta, Yiguo Zhang, Michael L Freeman, Suresh C Sikka, Asim B Abdel-Mageed, Debasis Mondal (2014) Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.PLoS One. 2014 Jan 22;9(1):e87204. doi: 10.1371/journal.pone.0087204. Yiguo Zhang*, Hayes JD (2013) The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity. Sci Rep._Nature.com 3:2006 (1-16). doi: 10.1038/srep02006. H Xiao, F Lü, D Stewart, Yiguo Zhang* (2013) Mechanisms underlying chemopreventive effects of lavonoids via multiple signaling nodes within Nrf2-ARE and AhR-XRE gene regulatory networks. Current Chemical Biology 7 (2): 151-176 Chowdhry S, Yiguo Zhang, McMahon M, Sutherland C, Cuadrado A, Hayes JD (2012-2013) .Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene. 2013 Aug 8;32(32):3765-81. Epub 2012 Sep 10. doi:10.1038/onc.2012. 388. PMID:22964642 Julia Li Zhong, Li Yang, Fenglin Lü, Han Xiao, Feifei Tian, Feng Zhu, and YIGUO ZHANG* (2011) UVA, UVB and UVC induce differential response signaling pathways converged on the eIF2a phosphorylation. Photochem. & Photobiol. 87, 1092-1104. Yongjun Wu, Yiming Wu, Jiang Wang, Zhen Yan, Lingbo Qu, Bingren Xiang and YIGUO ZHANG (2011) An optimal tumor marker group-coupled artificial neural network for diagnosis of lung cancer. Expert Systems with Applications 38, 11329-11334. YIGUO ZHANG* and John D. Hayes (2010). Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane. Biochem. J. 430, 497-510. YIGUO ZHANG* (2009). Molecular and cellular control of the Nrf1 transcription factor: An integral membrane glycoprotein. Erschienen bei: VDM Verlag Publishing House Ltd, Germany in May 2009 YIGUO ZHANG*, Akira Kobayashi, Masayuki Yamamoto, and John D. Hayes (2009). The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence. J. Biol. Chem. 284, 3195-3210 YIGUO ZHANG*, John M. Lucocq, and John D. Hayes (2009) The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by tert-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochem. J. 418, 293-310 YIGUO ZHANG*, John M. Lucocq, Masayuki Yamamoto, and John D. Hayes. (2007) The N-terminal homology box 1 (NHB1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochem. J. 408, 161-172 YIGUO ZHANG*, Dorothy H. Crouch, Masayuki Yamamoto, and John D. Hayes. (2006) Negative regulation of the Nrf1 transcription factor by its N-terminal Domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem. J. 399, 373-395 Tatyana A. Zykova, Feng Zhu, YIGUO ZHANG, Ann M. Bode and Zigang Dong. (2007) Involvement of ERKs, RSK2 and PKR in UVA-induced signaling transduction toward phosphorylation of eIF2a. Carcinogenesis 28, 1543-1551 Feng Zhu, Bu Young Choi, Wei-Ya Ma, Zhongliang Zhao, YIGUO ZHANG, Yong Yeon Cho, Hong Seok Choi, Akira Imamoto, Ann M. Bode and Zigang Dong. (2006) COOH-Terminal Src Kinase– Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation. Cancer Research 66, 5729-5736 Yong-Yeon Cho, Zhiwei He, YIGUO ZHANG, Hong Seok Choi, Feng Zhu, Bu Young Choi, Bong Seok Kang, Wei-Ya Ma, Ann M. Bode, and Zigang Dong. (2005) The p53 Protein Is a Novel Substrate of Ribosomal S6 Kinase 2 and a Critical Intermediary for Ribosomal S6 Kinase 2 and Histone H3 Interaction. Cancer Research 65, 3596-3603 Tatyana A. Zykova, YIGUO ZHANG, Feng Zhu, Ann M. Bode, and Zigang Dong (2005). The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. Carcinogenesis 26(2), 331-342 YIGUO ZHANG, Yong Yeon Cho, Brandon L. Petersen, Feng Zhu, and Zigang Dong. (2004) Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1. Carcinogenesis 25, 1165-1175 YIGUO ZHANG, Yong-Yeon Cho, Brandon L. Petersen, Ann M. Bode, Feng Zhu, and Zigang Dong. (2003). Ataxia telangiectasia mutated protein, MAPKs and RSK2 are involved in the phosphorylation of STAT3. J. Biol. Chem. 278, 12650-12659 YIGUO ZHANG, Wei-Ya Ma, Akira Kaji, Ann M. Bode, and Zigang Dong (2002). Requirement of ATM in UVA-induced signaling and apoptosis. J. Biol. Chem. 277, 3124-3131 YIGUO ZHANG, Guangming Liu, and Zigang Dong (2001). MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J. Biol. Chem. 276, 42534-42542 YIGUO ZHANG, Ziming Dong, Masaaki Nomura, Shuping Zhong, Nanyue Chen, Ann M. Bode, and Zigang Dong (2001). Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J. Biol. Chem. 276, 20913-20923 YIGUO ZHANG, Shuping Zhong, Ziming Dong, Nanyue Chen, Ann M. Bode, Wei-ya Ma and Zignag Dong (2001). UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J. Biol. Chem. 276, 14572-14580 YIGUO ZHANG, Peter Mttjus, Patricia C. Schmid, Zimng Dong, Shuping Zhong, Wei-Ya Ma, Rhoderick E. Brown, Ann M. Bode, Harald H. O. Schmid, and Zigang Dong (2001). Involvement of the acid sphingomyelinase pathway in UVA-induced apoptosis. J. Biol. Chem. 276, 11775-11782 8.联系方式(*必填) Email: yuancaix@126.com |
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