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[求助] Hit to lead

The hit-to-lead optimization paradigms are also dependent on
the screening technology used for hit discovery. We have here
collated many of the published success stories of hit-to-lead optimization
and analyzed them in relation to the technologies they
used (Table 2). The hit-to-lead process for drug-like hits might
involve techniques such as hit evolution, (bio)isosteric replacements
and hit fragmentation, or any combination of ,
想知道这段话中Hit to lead 是什么意思？

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