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The hit-to-lead optimization paradigms are also dependent on the screening technology used for hit discovery. We have here collated many of the published success stories of hit-to-lead optimization and analyzed them in relation to the technologies they used (Table 2). The hit-to-lead process for drug-like hits might involve techniques such as hit evolution, (bio)isosteric replacements and hit fragmentation, or any combination of , ÏëÖªµÀÕâ¶Î»°ÖÐHit to lead ÊÇʲôÒâ˼£¿ |
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