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几句论文求大神翻译成中文 谢谢
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Another issue that needs to be explained is that the PHBVPEGMAL surface (Figure 3c) does not suppress the cell growth significantly as we expected because of the presence of PEG if comparedwithPHBV- NH2 and PHBV-RGDsurfaces (Figure 3a,d). The reason is likely to be the reactive maleimide groups at the end of PEG. The maleimide group reacts specifically with sulfhydryl groups when the pHof the reaction mixture is between pH 6.5 and 7.5 and forms a stable thioether linkage. Because sulfhydryls are present in most proteins and the cell culturemedium containsmany proteins, it is very possible that the proteins in the culturemedium are chemically bound to the end of PEG by maleimide groups, further promoting cell adhesion and proliferation. |
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