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(Senior) Post Doctoral Position in synthesis and testing of antimicrobial peptides

The Centre for Antimicrobial Bioengineering at the School of Chemical and Biomedical Engineering, Nanyang Technological University (Singapore) is seeking candidates to work as Post-Doctoral researchers to design and synthesize antimicrobial peptides their conjugates which will be used antimicrobial drugs.

The candidate will work in an integrated team of Microbiologists and Chemists to design and synthesize new antimicrobial peptides that will inhibit Gram negative and Gram positive pathogens as well as Mycobacteria and fungal pathogens.  The goal is to design and synthesize active compounds, that are non-toxic to mammalian cells, and that represent lead compounds for drug development.  

Environment
The work will be conducted within the Centre for Antimicrobial Bioengineering (CAMB) in collaboration with the Singapore Centre for Environmental Life Sciences and Engineering (SCELSE). CAMB has core expertise in peptide and polymer synthesis and structure-property activity studies. The polymer synthesis involves various synthetic chemical methods such as solid-phase synthesis (FMOC chemistry), glycochemistry, RAFT, NCA, block copolymer chemistry and physics, etc.

Responsibilities
The candidate will work with PhD students as well as research staff to achieve the project goals
Will develop and execute experiments aimed at the synthesis and characterization of novel antimicrobial polypeptides that are highly potent but non-toxic.
Prepare technical reports for the program PIs and present data at regular group meetings
Draft research publications
Assist with organization and management of the research team

Requirements
PhD in biochemistry, or peptide chemistry.
Expertise in polypeptide synthesis methods such as solid phase synthesis, glycochemistry,  and organic techniques.
Capacity to develop and interpret peptide structure-assembly relationship, antimicrobial activity and polymer self-assembly behavior.
Familiarity with testing techniques which shall include CD spectroscopy, MIC testing, hemolysis, confocal microscopy, animal culture and handling.
Expertise in developing and interpreting experiments for design and synthesis of novel antimicrobial peptides.
Strong track record of publication in related disciplines
Ability to work in a multidisciplinary team
Good interpersonal and communication skills, oral and written, as well as organizational  

Contact:
Professor Mary Chan, Director for Centre for Antimicrobial Bioengineering
mbechan@ntu.edu.sg
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