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Athrun_Zala铜虫 (小有名气)
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[求助]
求生物受体类翻译（英译中）
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由于小弟对生物领域完全不懂，求大神帮忙翻译以下内容： The nAChRs are homo- or heteromeric pentamers of structurally related subunits that encompass an extracellular N-terminal domain which has six distinct regions (loops A–F) involved in ligand binding, as well as a Cys-Cys loop, four Cterminal transmembrane-spanning domains (TM1–TM4) that form the cation-permeable channel, and an intracellular region extending from TM3 to TM4.[32] Each subunit comprises approximately 500 amino acids, and is encoded by a separate gene, and possesses the four transmembrane domains (TM1–TM4). The subunits are oriented around the central pore, such that the resulting transmembrane ion channel is formed by a pentameric arrangement of the TM2 helical segments contributed by each of the five subunits. In vertebrates, 17 nAChR subunits have been identified (a1– a10, b1–b4, g, d, and e), which can coassemble to generate a diverse family of nAChR subtypes. In insects, several genes have been identified that encode multiple nAChR subunits, which suggests the existence of a range of subtypes of insect receptors across species.[33] As an agonist-gated ion channel complex for excitatory neurotransmission, the nAChR is widely distributed in the insect CNS, and constitutes a major target for insecticide action. Compared to their vertebrate counterparts, the functional architecture, diversity, and threedimensional (3D) tertiary structure of native insect nAChRs are poorly understood.[ |
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Athrun_Zala: 金币+80, 翻译EPI+1, ★★★★★最佳答案 2015-03-17 16:36:18
Athrun_Zala: 金币+80, 翻译EPI+1, ★★★★★最佳答案 2015-03-17 16:36:18
| nAChRs 是由五个结构相似的亚基组成的同聚体或异聚体, N末端位于胞外, 含有6个明显的环状结构(环A-F),可与配体结合. 4个位于C末端的跨膜区(TM1–TM4)和一个Cys-Cys 环 形成了一个阳离子的通道. TM3和TM4之间则构成了胞内区. 每个亚基由独立的基因编码, 长约500个氨基酸,含4个跨膜区(TM1–TM4). 亚基围绕一个中心孔排列, 由每个亚基的TM2螺旋结构共同构成一个五边形的跨膜离子通道. 在脊椎动物中, 一共发现了17 个nAChR亚基 (a1– a10, b1–b4, g, d, and e), 它们按不同组合, 构成了多种类型nAChR家族. 在昆虫中, 数个编码nAChR亚基的基因已经被发现, 表明存在多个跨种的昆虫受体类型. 作为一种促效门控离子通道的兴奋型离子传导, nAChR广泛存在于昆虫的中枢神经系统中, 也是杀虫剂的主要作用靶点. 与 脊椎动物的nAChR相比, 昆虫nAChR的功能性结构, 多样性和三维结构都了解不多. |
2楼2015-03-17 15:38:25
