SYBYL 8.0 is the latest release of the New Tripos International's leading
molecular modeling and computational informatics platform.
If you haven't used SYBYL in a while you owe it to yourself to have a fresh
look with SYBYL 8.0! You'll be surprised at the improvements including:
Exciting new products:
Topomer CoMFA - a 3D QSAR tool that automates the creation of models for
predicting the biological activity or properties of compounds. Topomer CoMFA
models can be created in minutes, not days, can easily be used by both QSAR
experts and QSAR non-experts, and the results are often comparable to
traditional CoMFA analysis.
Topomer Search - an exceptionally fast 3D ligand-based virtual screening tool
that has been demonstrated to be effective for both lead hopping and scaffold
hopping. Screen for whole molecules, side chains, or scaffolds using
conformationally independent topomer similarity.
Surflex-Sim - generates molecular alignments and hypotheses of bioactive
ligand conformations for 3D ligand based design and virtual screening
Enhanced protein modeling capabilities:
Support for new, remediated PDB format from the RCSB.
Build terminal loops within Advanced Protein Modeling's ORCHESTRAR technology
allowing a complete model to be created. Also manage cofactors, ligands,
waters and metals with the ORCHESTRAR technology.
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