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wwzzchem

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title:The preliminary evaluation on cholesterol-modified pullulan as a drug nanocarrier. Drug Deliv, 2014; 21(7): 501–508
doi:10.3109/10717544.2014.895068
published: 2014 Informa Healthcare USA, Inc
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wwzzchem: 金币+5, ★★★很有帮助, 有用 2015-03-04 10:03:39
wwzzchem: 金币+5 2015-08-27 16:37:47
he preliminary evaluation on cholesterol-modified pullulan as a drug nanocarrier
作者:Shen, SG (Shen, Shigang)[ 1 ] ; Li, HY (Li, Haiying)[ 1 ] ; Yang, WZ (Yang, Wenzhi)[ 2 ]
DRUG DELIVERY
卷: 21  期: 7  页: 501-508
DOI: 10.3109/10717544.2014.895068
出版年: NOV 2014
查看期刊信息
摘要
To further develop cholesterol-modified pullulan self-aggregated nanoparticles (CHSPNs) as a drug nanocarrier, CHSP was synthesized and characterized. Its cholesterol degree determined by H-1 NMR was 5.2 cholesterol groups per hundred glucose units. CHSPNs were prepared in aqueous media and characterized by dynamic laser light-scattering (DLS), zeta potential and transmission electron microscopy (TEM). These nanoparticles were almost spherical in shape, and the zeta potentials of CHSPNs were near zero in aqueous media. CHSPNs can be stable at least 2 months with no significant size and zeta potential changes. Single dose toxicity test in mice was investigated for the safety evaluation of CHSPNs as a drug nanocarrier, and the result showed CHSPNs were well tolerated at the dose of 200 mg/kg in mice. Epirubicin (EPI)-loaded CHSPNs (EPI-CHSPNs) were prepared and the in vivo pharmacokinetics and biodistribution were studied. Compared with the EPI solution, EPI-CHSPNs have exhibited higher plasma drug concentration, longer half-life time (t(1/2)) and the larger area under-the-curve (AUC). Moreover, the drug level of EPI-CHSPNs increased in liver and decreased in heart. The results indicated that CHSPNs were stable, safe and may be a promising drug delivery carrier.
关键词
作者关键词:Cholesterol-modified pullulan; epirubicin; nanoparticles; pharmacokinetics; stability; toxicity
KeyWords Plus:HYDROPHOBIZED POLYSACCHARIDE; BEARING PULLULAN; IN-VIVO; NANOPARTICLES; CARRIER; PHARMACOKINETICS; STABILIZATION; SYSTEMS; CLEARANCE; STABILITY
作者信息
通讯作者地址: Shen, SG (通讯作者)
显示增强组织信息的名称        Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China.
地址:
显示增强组织信息的名称        [ 1 ] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
显示增强组织信息的名称        [ 2 ] Chinese Acad Med Sci, Peking Union Med Coll, Inst Biomed Engn, Tianjin, Peoples R China
电子邮件地址:pharm_shen@163.com; wenzhi_yang@sina.com
基金资助致谢
基金资助机构        授权号
Natural Science Foundation of Hebei Province        
H2012201069
B2013201181
Science and Technology Planning Project of Hebei Province        
13272705
Natural Science Foundation of Hebei University, China        
2010-193
查看基金资助信息   
出版商
INFORMA HEALTHCARE, TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
类别 / 分类
研究方向harmacology & Pharmacy
Web of Science 类别harmacology & Pharmacy
文献信息
文献类型:Article
语种:English
入藏号: WOS:000344800500001
PubMed ID: 24625263
ISSN: 1071-7544
eISSN: 1521-0464
其他信息
IDS 号: AT2YM
Web of Science 核心合集中的 "引用的参考文献": 37
Web of Science 核心合集中的 "被引频次": 0

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2楼2015-03-04 09:58:13
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wwzzchem

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引用回帖:
2楼: Originally posted by Paulwolf at 2015-03-04 09:58:13
he preliminary evaluation on cholesterol-modified pullulan as a drug nanocarrier
作者:Shen, SG (Shen, Shigang) ; Li, HY (Li, Haiying) ; Yang, WZ (Yang, Wenzhi)
DRUG DELIVERY
卷: 21  期: 7  页: 501 ...

这个信息,表明已经被SCI检索了,对吗?
3楼2015-03-04 10:02:08
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