| 查看: 390 | 回复: 20 | ||
| 当前主题已经存档。 | ||
| 【悬赏金币】回答本帖问题，作者chendiqing将赠送您 30 个金币 | ||
chendiqing铁杆木虫 (知名作家)
|
[求助]
查文献的题目，一个5金币，难找的一个10~20金币啊【已解决，谢谢大家】
|
|
|
各位兄弟姐妹们，帮忙查一下以下文献的题目啊，就只它文献的题目就可以了，找到一个5金币，难找的一个10~20金币不等，拜托了啊~~~~ 1，Biginelli , P. Gazz. Chim. Ital . 1893 , 23 , 360. 2，Kappe , C. O. Tetrahedron 1993 , 49 , 6937. 3，Grover , G. J . ; Dzwonczyk , S. ; McMullen , D. M. ; Grover ,C. S. ; Sleph , P. G. ; Moreland , S. J . J . Cardiovasc. Pharmacol . 1995 , 26 , 289. 4，Atwal , K. S. ; Swanson , B. N. ; Unger , S. E. ; Floyd , D. M. ; Moreland , S. ; Hedberg , A. ; O′eilly , B. C. J . Med. Chem. 1991 , 34 , 806. 5，Rovnyak , G. C. ; Atwal , K. S. ; Hedberg , A. ; Kim2 ball , S. D. ; Moreland , S. ; Gougoutas , J . Z. ; O’eil2ly , B. C. ; Schwartz , J . ; Malley , M. F. J . Med.Chem. 1992 , 35 , 3254. 6，Nagarathnam , D. ; Miao , S. W. ; Lagu , B. ; Chiu , G. ; Fang , J . ; MDhar , T. G. ; Zhang , J . ; Tyagarajan , S. ; Marzabadi , M. R. ; Zhang , F. Q. ; Wong , W. C. ; Sun , W. Y. ; Tian , D. ; Wetzel , J . M. ; Forray , C. ; Chang , R. S. L. ;Broten , T. P. ; Ransom , R. W. ;Schorn , T. W. ; Chen , T. B. ; O′Malley , S. ;Kling , P. ; Schneck , K. ; Benedesky , R. ; Harrell , C. M. ; Vyas , K. P. ;Gluchowski , C. J . Med. Chem. 1999 , 42 , 4764. 7，Barrow , J . C. ; Nantermet , P. G. ; Selnick , H. G. ; Glass , K. L. ; Rittle , K. E. ; Gilbert , K. F. ; Steele , T. G. ; Homnick , C. F. ; Freidinger , R. M. ; Ransom , R. W. ; Kling , P. ; Reiss , D. ; Broten , T. P. ; Schorn , T. W. ; Chang , R. S. L. ; O′Malley , S. S. ; Olah , T. V. ; Ellis , J . D. ; Barrish , A. ; Kassahun , K. ; Leppert , P. ; Nagarathnam , D. ; Forray , C. J . Med. Chem. 2000 , 43 , 2703. 8，Ma , Y. ; Qian , C. ; Wang , L. ; Yang , M. J . Org. Chem. 2000 , 65 , 3864. 9，Ranu , B. C. ; Hajra , A. ; Jana , U. J . Org. Chem. 2000 , 65 , 6270. 10，Wipf , P. ; Cunningham , A. Tetrahedron Lett . 1995 , 36 ,7819. 11，Studer , A. ; Jeger , P. ; Wipf , P. ; Curran , D. P. J . Org.Chem. 1997 , 62 , 2917. [ Last edited by zzgyb on 2008-7-17 at 10:57 ] |
回复此楼» 猜你喜欢
求调剂
已经有4人回复
-
求调剂
已经有4人回复
-
277材料科学与工程080500求调剂
已经有4人回复
-
学校已经提交到NSFC，还能修改吗？
已经有9人回复
-
286分人工智能专业请求调剂愿意跨考！
已经有7人回复
-
286求调剂
已经有6人回复
-
280求调剂
已经有10人回复
-
材料学硕301分求调剂
已经有4人回复
-
278求调剂
已经有8人回复
-
求助
已经有5人回复
2楼2008-06-16 22:09:27
3楼2008-06-16 22:13:01
★ ★ ★ ★ ★
chendiqing(金币+5,VIP+0):哇哦，谢谢哥们你啊~~~~
chendiqing(金币+5,VIP+0):哇哦，谢谢哥们你啊~~~~
|
3.Titre du document / Document title Pharmacologic profile of the dihydropyrimidine calcium channel blockers SQ 32,547 and SQ 32,946 Auteur(s) / Author(s) GROVER G. J. ; DZWONCZYK S. ; MCMULLEN D. M. ; NORMANDIN D. E. ; PARHAM C. S. ; SLEPH P. G. ; MORELAND S. ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s) Bristol-Myers Squibb pharmaceutical res. inst., dep. pharmacology, Princeton NJ 08543, ETATS-UNIS Résumé / Abstract SQ 32,926 and SQ 32,547, two dihydropyrimidine calcium channel blockers, were characterized as potent inhibitors of depolarization-induced contractions of isolated smooth muscle preparations. In rat aorta, the IC50 values were 5.5 nM for SQ 32,547 and 8.1 nM for SQ 32,926, values which compare favorably with that of 2.9 nM for nifedipine. The dihydropyrimidines were also tested in a model of stable angina : pacing-induced ischemia in dogs. Both SQ 32,547 and SQ 32,926 reduced the ST-segment elevation observed in vehicle-treated animals. No significant changes in hemodynamic status were detected, suggesting that a reduction in cardiac work secondary to afterload reduction was probably not a major contributor to the protective effects. Neither was increased coronary blood flow important for the antiischemic outcome because no significant effects of the dihydropyrimidines were observed on ischemic regional blood flow. SQ 32,547 was also studied in globally ischemic, isolated rat hearts. In this model, SQ 32,547 was protective because it significantly reduced contracture formation and lactate dehydrogenase (LDH) release. Washing out the effect of SQ 32,547 in isolated hearts and smooth muscles was difficult, presumably due to its lipophilicity. In the smooth muscle preparations, the effects of both nifedipine and SQ 32,926 were much more easily washed out. As with other calcium channel blockers, increasing the antiischemic effects of SQ 32,547 was associated with a higher cost in terms of cardiac function. In summary, the two novel dihydropyrimidines, SQ 32,547 and SQ 32,926, showed antiischemic properties in animal models. Revue / Journal Title Journal of cardiovascular pharmacology ISSN 0160-2446 CODEN JCPCDT Source / Source 1995, vol. 26, no2, pp. 289-294 (24 ref.) Langue / Language Anglais Editeur / Publisher Lippincott, Hagerstown, MD, ETATS-UNIS (1979) (Revue) Mots-clés anglais / English Keywords Calcium antagonist ; Antiïschemic ; Angina pectoris ; Chemotherapy ; Treatment ; Smooth muscle ; Heart ; Rat ; Animal ; In vivo ; In vitro ; Rodentia ; Mammalia ; Vertebrata ; Cardiovascular disease ; Coronary heart disease ; Mots-clés français / French Keywords Antagoniste calcium ; Antiischémique ; Angine poitrine ; Chimiothérapie ; Traitement ; Muscle lisse ; Coeur ; Rat ; Animal ; In vivo ; In vitro ; SQ 32 547 ; SQ 32 946 ; Dihydropyrimidine dérivé ; Cardioprotecteur ; Rodentia ; Mammalia ; Vertebrata ; Appareil circulatoire pathologie ; Cardiopathie coronaire ; Mots-clés espagnols / Spanish Keywords Antagonista calcio ; Antiisquémico ; Angina pectoris ; Quimioterapia ; Tratamiento ; Músculo liso ; Corazón ; Rata ; Animal ; In vivo ; In vitro ; Rodentia ; Mammalia ; Vertebrata ; Aparato circulatorio patología ; Cardiopatía coronaria ; Localisation / Location INIST-CNRS, Cote INIST : 18065, 35400005361515.0140 |
4楼2008-06-16 22:15:46
★ ★ ★ ★ ★
chendiqing(金币+5,VIP+0):谢谢了啊~~~~
chendiqing(金币+5,VIP+0):谢谢了啊~~~~
|
5.Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1, 4-dihydropyrimidine-5 文献下载地址：http://pubs.acs.org/cgi-bin/abst ... 3.pdf?sessid=6006l3 |
5楼2008-06-16 22:20:47
fjxin2002
木虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 2550.7
- 散金: 21
- 红花: 2
- 帖子: 735
- 在线: 24.9小时
- 虫号: 248107
- 注册: 2006-05-03
- 性别: GG
- 专业: 能源化工
6楼2008-06-16 22:27:14
7楼2008-06-16 22:27:50
8楼2008-06-16 22:28:57
9楼2008-06-16 22:31:04
fjxin2002
木虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 2550.7
- 散金: 21
- 红花: 2
- 帖子: 735
- 在线: 24.9小时
- 虫号: 248107
- 注册: 2006-05-03
- 性别: GG
- 专业: 能源化工
★ ★ ★ ★ ★
chendiqing(金币+5,VIP+0):恩，谢谢啊，虽然稍微慢了一步，但金币还是要给你的啊，哈哈哈~~~~
chendiqing(金币+5,VIP+0):恩，谢谢啊，虽然稍微慢了一步，但金币还是要给你的啊，哈哈哈~~~~
|
9. Indium(III) Chloride-Catalyzed One-Pot Synthesis of Dihydropyrimidinones by a Three-Component Coupling of 1,3-Dicarbonyl Compounds, Aldehydes, and Urea: An Improved Procedure for the Biginelli Reaction Ranu, B. C.; Hajra, A.; Jana, U. J. Org. Chem.; (Note); 2000; 65(19); 6270-6272. DOI: 10.1021/jo000711f |
10楼2008-06-16 22:31:09
