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PHBV films are activated by ammonia plasma treatment to produce amino groups on the surface. RGD peptides are then grafted to the activated PHBV films through a PEG-containing cross-linker with a hydroxysuccinimidyl group at one end and a maleimide group at the other end. XPS analyses of the modified surfaces after each reaction step indicate that the RGD-containing peptides have been covalently grafted onto PHBV films. The results of the cell studies have confirmed that the RGD-modified PHBV films exhibit a distinctly improved cellular compatibility. |
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