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小木虫论坛-学术科研互动平台 » 生物医药区 » 分子生物 » 分子生理 » Cambridge2007年Genes and Common Diseases. Genetics in Modern Medicine
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[资源] Cambridge2007年Genes and Common Diseases. Genetics in Modern Medicine

Contents
List of Contributors page vii
Foreword xiii
Section 1: Introductory Principles
1 Genes and their expression 3
Dirk-Jan Kleinjan
2 Epigenetic modification of chromatin 20
Donncha Dunican, Sari Pennings and
Richard Meehan
3 Population genetics and disease 44
Donald F. Conrad and Jonathan K. Pritchard
4 Mapping common disease genes 59
Naomi R. Wray and Peter M. Visscher
5 Population diversity, genomes and
disease 80
Gianpiero L. Cavalleri and David B. Goldstein
6 Study design in mapping complex
disease traits 92
Harry Campbell and Igor Rudan
7 Diseases of protein misfolding 113
Christopher M. Dobson
8 Aging and disease 132
Thomas T. Perls
9 The MHC paradigm: genetic variation
and complex disease 142
Adrian P. Kelly and John Trowsdale
v
10 Lessons from single gene disorders 152
Nicholas D. Hastie
11 Environment and disease 164
A. J. McMichael and K. B. G. Dear
12 Contemporary ethico-legal issues in
genetics 176
Renate Gertz, Shawn Harmon and
Geoffrey Pradella
Section 2: Common Medical Disorders
13 Developmental disorders 201
Stephen P. Robertson and Andrew O. M. Wilkie
14 Genes, environment and cancer 213
D. Timothy Bishop
15 The polygenic basis of breast cancer 224
Paul D. P. Pharoah and Bruce A. J. Ponder
16 TP53: A master gene in normal
and tumor suppression 233
Pierre Hainaut
17 Genetics of colorectal cancer 245
Susan M. Farrington and Malcolm G. Dunlop
18 Genetics of autoimmune disease 268
John I. Bell and Lars Fugger
19 Susceptibility to infectious diseases 277
Andrew J. Walley and Adrian V. S. Hill
20 Inflammatory bowel diseases 302
Jean-Pierre Hugot
21 Genetic anemias 316
W. G. Wood and D. R. Higgs
22 Genetics of chronic disease: obesity 328
I. Sadaf Farooqi and Stephen O’Rahilly
23 Type 2 diabetes mellitus 344
Mark I. McCarthy
24 Genetics of coronary heart disease 359
Rossi Naoumova, Stuart A. Cook, Paul Cook and
Timothy J. Aitman
25 Genetics of hypertension 377
B. Keavney and M. Lathrop
26 Obstructive pulmonary disease 391
Bipen D. Patel and David A. Lomas
27 Skeletal disorders 406
Robert A. Colbert
28 The genetics of common skin diseases 427
Jonathan Rees
29 Molecular genetics of Alzheimer’s
disease and other adult-onset
dementias 439
P. H. St George-Hyslop
30 Major psychiatric disorders in
adult life 454
Amanda Elkin, Sridevi Kalidindi,
Kopal Tandon and Peter McGuffin
31 Speech and language disorders 469
Gabrielle Barnby and Anthony J. Monaco
32 Common forms of visual handicap 488
Alan Wright
33 Genetic and environmental influences
on hearing impairment 505
Karen P. Steel
34 Pharmacogenomics: clinical
applications 516
Gillian Smith, Mark Chamberlain and
C. Roland Wolf
Index 529
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