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[资源] Cambridge2011年Nerve and Muscle 4th ed

Chapter 1 Structural organization of the nervous system 1
1.1 Nervous systems 1
1.2 The anatomy of a neuron 2
1.3 Non-myelinated nerve fibres 2
1.4 Myelinated nerve fibres 4
Chapter 2 Resting and action potentials 9
2.1 Electrophysiological recording methods 9
2.2 Intracellular recording of the membrane potential 11
2.3 Extracellular recording of the nervous impulse 13
2.4 Excitation 16
Chapter 3 The ionic permeability of the nerve membrane 21
3.1 Structure of the cell membrane 21
3.2 Distribution of ions in nerve and muscle 24
3.3 The genesis of the resting potential 25
3.4 The Donnan equilibrium system in muscle 27
3.5 The active transport of ions 28
Chapter 4 Membrane permeability changes during
excitation 34
4.1 The impedance change during the spike 34
4.2 The sodium hypothesis 34
4.3 Voltage-clamp experiments 39
4.4 Patch-clamp studies 47
Chapter 5 Voltage-gated ion channels 49
5.1 cDNA sequencing studies 49
5.2 The primary structure of voltage-gated ion channels 49
5.3 The sodium gating current 53
5.4 The screw-helical mechanism of voltage-gating 55
5.5 The ionic selectivity of voltage-gated channels 59
Chapter 6 Cable theory and saltatory conduction 63
6.1 The spread of potential changes in a cable system 63
6.2 Saltatory conduction in myelinated nerves 65
6.3 Factors affecting conduction velocity 70
6.4 Factors affecting the threshold for excitation 71
6.5 After-potentials 72
Contents
vi CONTENTS
Chapter 7 Neuromuscular transmission 74
7.1 The neuromuscular junction 74
7.2 Chemical transmission 75
7.3 Post-synaptic responses 76
7.4 Pre-synaptic events 84
Chapter 8 Synaptic transmission in the nervous system 87
8.1 Synaptic excitation in motoneurons 87
8.2 Inhibition in motoneurons 90
8.3 Interaction of IPSPs with EPSPs 91
8.4 Pre-synaptic inhibition 92
8.5 Slow synaptic potentials 92
8.6 G-protein-linked receptors 94
8.7 Electrotonic synapses 97
Chapter 9 The mechanism of contraction in skeletal muscle 99
9.1 Anatomy 99
9.2 The structure of the myofibril 100
9.3 The sliding-filament theory 103
9.4 The molecular basis of contraction 106
Chapter 10 The activation of skeletal muscle 112
10.1 Ion channels in the membrane of skeletal muscle 112
10.2 Action potential generation in surface and tubular
membranes of skeletal muscle 113
10.3 Excitation–contraction coupling in skeletal muscle 115
10.4 Involvement of Ca2+ ions in excitation–contraction
coupling 116
10.5 Internal membrane systems 118
10.6 Triggering molecules for the release of sarcoplasmic
reticular calcium 119
10.7 Tubular voltage detection mechanisms triggering
excitation–contraction coupling 121
10.8 Calcium release from the sarcoplasmic reticulum
through the ryanodine receptor 124
10.9 Triggering of ryanodine receptor opening through
configurational coupling to the dihydropyridine receptor 125
10.10 Restoration of sarcoplasmic reticular calcium following
repolarization 126
10.11 Overview of excitation–contraction coupling in skeletal
muscle 128
Chapter 11 Contractile function in skeletal muscle 129
11.1 Isometric and isotonic contractions 129
11.2 Isometric twitch and tetanus 130
Contents vii
11.3 Isotonic contractions 132
11.4 Energetics of contraction 135
11.5 Work and power 135
11.6 Heat production 137
11.7 Efficiency 137
11.8 The energy source 138
11.9 Muscular fatigue 140
11.10 Energy balances during muscular exercise 141
11.11 Ionic and osmotic balances during muscular exercise 142
11.12 The effects of training 144
Chapter 12 Cardiac muscle 146
12.1 Structure and organization of cardiac cells 146
12.2 The electrical initiation of the heartbeat 146
12.3 The cardiac action potential 148
12.4 Ionic currents in cardiac muscle 149
12.5 The electrocardiogram 152
12.6 Cardiac excitation–contraction coupling 154
12.7 Nervous control of the heart 157
12.8 Cardiac arrhythmogenesis 158
Chapter 13 Smooth muscle 162
13.1 Structure 162
13.2 Excitation 163
13.3 Excitation–contraction coupling 164
13.4 Contractile mechanism 165
13.5 Mechanical properties 167
Further reading 169
References 170
Index 178

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2015-02-27 18:49:28, 5.27 M