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| The histochemical and immunohistochemical studies have not clarified the histogenesis of spiradenoma. The frequent association of spiradenoma and cylindroma, a likely apocrine neoplasm, and the sporadic association of spiradenomawith neoplasms with follicular differentiation such as trichoepithelioma {2500}, support an apocrine line of differentiation for spiradenoma on the basis of the common embryologic origin for the three elements of the folliculo-sebaceous-apocrine unit. This is furthermore supported by some examples of spiradenoma that show decapitation secretion in the cells lining the luminal border of the tubular structures. Therefore, the qualifying term of ¡°eccrine¡± that almost invariably is applied to spiradenoma is inaccurate. |
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