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C o n t e n t s Prologue by Ahmed H. Zewail xi Chapter 1 The Preoccupations of Twenty-First-Century Biology 1 David Baltimore Chapter 2 The World as Physics, Mathematics and Nothing Else 7 Alexander Varshavsky Chapter 3 Physical Biology: 4D Visualization of Complexity 23 Ahmed H. Zewail Chapter 4 Revolutionary Developments from Atomic to Extended Structural Imaging 51 John Meurig Thomas Chapter 5 Physical Biology at the Crossroads 115 Carlos J. Bustamante Chapter 6 The Challenge of Quasi-Regular Structures in Biology 137 Roger D. Kornberg Chapter 7 The Future of Biological X-Ray Analysis 145 Douglas C. Rees Chapter 8 Reinterpreting the Genetic Code: Implications for Macromolecular Design, Evolution and Analysis 165 David A. Tirrell viii Contents Chapter 9 Designing Ligands to Bind Tightly to Proteins 189 George M. Whitesides, Phillip W. Snyder, Demetri T. Moustakas, and Katherine A. Mirica Chapter 10 Biology by the Numbers 217 Rob Phillips Chapter 11 Eppur si muove 247 Michele Parrinello Chapter 12 Protein Folding and Beyond: Energy Landscapes and the Organization of Living Matter in Time and Space 267 Peter G. Wolynes Chapter 13 Protein Folding and Misfolding: From Atoms to Organisms 289 Christopher M. Dobson Chapter 14 A Systems Approach to Medicine Will Transform Healthcare 337 Leroy Hood Chapter 15 The Neurobiology of Consciousness 367 Christof Koch and Florian Mormann Chapter 16 Computer-Aided Drug Discovery: Physics-based Simulations from the Molecular to the Cellular Level 401 J. Andrew McCammon Chapter 17 Precision Measurements in Biology 411 Stephen R. Quake ix Contents Chapter 18 Potassium Channels and the Atomic Basis of Selective Ion Conduction 431 Roderick MacKinnon The 2007 Welch Award Papers 463 Chapter 19 Symmetry Breaking, Delocalization and Dynamics in Electron Transfer Systems 465 Noel S. Hush Chapter 20 The Initial Value Representation of Semiclassical Theory: A Practical Way for Adding Quantum Effects to Classical Molecular Dynamics Simulations of Complex Molecular Systems 505 William H. Miller Biographies 527 |
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