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[资源] Medicinal Chemistry: A Molecular and Biochemical Approach

Medicinal Chemistry: A Molecular and Biochemical Approach

Medicinal Chemistry: A Molecular and Biochemical Approach
By Thomas Nogrady, Donald F. Weaver
Publisher: Oxford University Press, USA
Number Of Pages: 672
Publication Date: 2005-07-27
ISBN-10 / ASIN: 0195104552
ISBN-13 / EAN: 9780195104554
Binding: Hardcover

Emphasizing the molecular action of drugs, this text incorporates recent findings from biochemical pharmacology along with the latest insights into the interactions of drugs with their receptors. It is organized by targets of drug action--endogenous messengers and their receptors, membranes, enzymes, and DNA, among others--and covers all drug groups and their therapeutic applications. This new edition has been thoroughly revised to provide expanded coverage of co-transmitters and neurohormones as well as adenosine receptors and calcium channel blockers. The chapter on drug distribution and metabolism has been extended, and the final chapter on principles of drug design outlines new methods, such as numerical techniques and computer graphics. Other new topics include atrial natriuretic factors, antiarrhythmic drugs, and DNA topoisomerase inhibitory mechanism of antitumor and antibacterial agents. The text is illustrated with hundreds of formulas and tables, and the index includes an extensive listing of drugs.

Summary: Better than Goodman and Gilman for pharmacy students
Rating: 5

I have taken two pharmacological type classes. One was pharmacology and the other was simply med chem. We used Goodman and Gilman in the pharmacology class and its just too dense. It has much information, but in my opinion, its not appropriate for a textbook. I thought that this book, by Nogrady is alot more managable. However, you need to have a background in biochemistry and organic chemistry to understand some of the topics in this book. It does a good job of explaining underlying mechanisms of pharmaceutical actions. Towards the end, it adopts a Goodman and Gilman approach and just starts listing drugs and their mechanism of action. However, Nogrady doesn't go on for 5 pages like Goodman and Gilman do. Its a bit more concise. Anyway, I don't mean to say that Goodman and Gilman is a bad book, quite the contrary, its an amazing book with more information than one could ever possibly want. Its just that if you want to understand pharmacology for a class, and are not browsing the pages for fun over a cup of tea, Nogrady may be the way to go.

http://rapidshare.com/files/1001 ... emical_Approach.pdf

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