| 查看: 274 | 回复: 2 | ||
[求助]
寻找文献
|
|
Pathogenesis and treatment of vascular cognitive impairment. Jellinger KA. Neurodegener Dis Manag. 2014 Dec;4(6):471-90. doi: 10.2217/nmt.14.37. 谢谢啦。。。。 |
回复此楼» 猜你喜欢
拟解决的关键科学问题还要不要写
已经有11人回复
-
救命帖
已经有5人回复
-
限项规定
已经有5人回复
-
为什么nbs上溴 没有产物点出现呢
已经有9人回复
-
招博士
已经有3人回复
-
存款400万可以在学校里躺平吗
已经有35人回复
-
最失望的一年
已经有18人回复
-
求推荐博导
已经有4人回复
-
求推荐英文EI期刊
已经有5人回复
-
疑惑？
已经有5人回复
|
Neurodegener Dis Manag. 2014 Dec;4(6):471-90. doi: 10.2217/nmt.14.37. Pathogenesis and treatment of vascular cognitive impairment. Jellinger KA. Abstract SUMMARY Vascular cognitive impairment (VCI) defines a continuum of disorders ranging from mild cognitive impairment to full-blown dementia, attributable to cerebrovascular causes. Major morphological types - multi-infarct encephalopathy, strategic infarct type, subcortical arteriosclerotic leukoencephalopathy, multilacunar state, postischemic encephalopathy - result from systemic, cardiac and local large or small vessel disease. Cognitive decline is commonly caused by widespread small cerebrovascular lesions (CVLs) affecting regions/networks essential for cognition, memory and behavior. CVLs often coexist with Alzheimer-type and other pathologies, which interact in promoting dementia, but in many nondemented elderly individuals, mixed brain pathologies are also present. Due to the high variability of CVLs, no validated clinical and neuropathological criteria for VCI are available. Cholinesterase inhibitors and memantine produce small cognitive improvement but without essential effect. Antihypertensive treatment, cardiovascular control and lifestyle modifications reducing vascular risk factors are essential. Given its growing health, social and economic burden, prevention and treatment of VCI are a major challenge of neuroscience. KEYWORDS: cerebrovascular lesions; large and small vessel disease; neuropathology; pathogenic factors; prevention and therapeutics; subcortical vascular lesions; vascular cognitive impairment PMID: 25531689 [PubMed - in process] Share on FacebookShare on TwitterShare on Google+ |
2楼2014-12-30 19:51:35
3楼2014-12-30 20:00:56