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niurena木虫 (正式写手)
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[求助]
转基因动物模型
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| To better model LKB1 deficient tumors, we took advantage of the wellcharacterized adenoviral cre-induced NSCLC models initiated by a conditionally activated K-ras oncogene (Lox-Stop-Lox-KrasG12D, hereafter called Kras), combined with mice bearing floxed alleles of p53or Lkb1(Farago et al., 2012). As previously reported (Chen etal., 2012; Ji et al., 2007), when p53deficiency or Lkb1-deficiency is combined with Kras activation, there is a dramatic increase in tumor burden leading to metastasis，在这段话中，是指老鼠提前进行转基因，同时携带Lox-Stop-Lox-KrasG12D和Lox-stop-lox-p53、Lox-stop-lox-Lkb1吗？然后再定时吸入重组腺病毒Cre酶，产生Kras-Lkb1L/L或者Kras-p53L/L的小鼠？请问Lkb1L/L是什么意思？请各位大侠指点？ |
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