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The efficacy of doxycycline and ciprofloxacin against an experimental tularaemia infection was assessed by comparing the median lethal dose (MLD) of Francisella tularensis Schu4 biotype A strain given intraperitoneally to antibiotic-treated and untreated mice. In untreated Porton outbred mice this was <1 cfu. Ciprofloxacin and doxycycline given at 40 mg/kg bd, initiated 48 h before infection and continued for 5 days after infection, afforded protection against intraperitoneal challenges of 3.7 x 106 cfu and 6.0 x 106 cfu, respectively. Ö÷ÒªÊÇ×îºóÒ»¾ä»°²»´ó¶®£¬intraperitoneal challenges of 3.7 x 106 cfu and 6.0 x 106 cfu¡£CFUÓÖÊÇʲôµ¥Î»ÄØ£¿»¹ÓУ¬bdÓ¦¸ÃÊÇÿÈÕÒ»´ÎµÄÒâ˼°É£¬¿ÉÊÇÕýÎÄÖÐ×÷ÕßдµÄÃ÷Ã÷ÊÇÿÈÕ¸øÒ©Á½´Î£ºThe antibiotics were given twice daily with a 12 h interval between each dose.ÊDz»ÊÇ×÷Õßд´íÁ˰¡£¿£¿ |
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