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[×ÊÔ´] Chem. Rev.11.25ÐÂÏÊÉÏÏߣºNanomaterials for Theranostics: Recent Advances

Nanomaterials for Theranostics: Recent Advances and Future Challenges
Eun-Kyung Lim,†,‡,¡ì Taekhoon Kim,¡Î,¡Í,¡ì Soonmyung Paik,#,∇ Seungjoo Haam,¡ð Yong-Min Huh,*,†
and Kwangyeol Lee*,¡Î
£¨68Ò³£¬907ƪÎÄÏ×£©
CONTENTS
1. Introduction A
1.1. What Are the Key Biological Processes Pertinent to Diseases, and How Can These Processes Be Monitored? C
1.2. What Is the Core Advantage of in Vivo Imaging over in Vitro Assays? C
1.3. What Are the Key Challenges That Need To Be Addressed To Overcome the Fundamental Limitations of in Vivo Imaging? C
2. Major Cancer Signaling Pathways and the
Concept of Targeted Delivery D
3. Design of Theranostic Nanoparticles F
3.1. Biomedical Payloads F
3.1.1. Imaging F
3.1.2. Therapeutics I
3.2. Carrier M
3.2.1. Polymers N
3.2.2. Lipids N
3.2.3. Dendrimers N
3.2.4. Inorganic Nanocarriers O
3.3. Surface Modifiers O
4. Pharmacokinetic and Pharmacodynamic Properties of Nanomaterial-Based Therapy P
5. Theranostic Nanomaterials R
5.1. Magnetic Nanoparticles R
5.1.1. Magnetic Nanoparticles as Imaging Agents T
5.1.2. Magnetic Nanoparticles as Drug Delivery Vehicles AD
5.1.3. Magnetic Nanoparticles as Hyperthermal Agents AE
5.1.4. Magnetic Nanoparticles as Anticancer Drugs AG
5.2. Quantum Dots (QDs) AH
5.2.1. Strategies for Reduced RES Uptake AI
5.2.2. Anticancer Drug and Other Chemical
Drug Delivery AI
5.2.3. Gene Delivery AJ
5.3. Metal Nanoparticles AJ
5.3.1. Metal Nanoparticle as Imaging Agent AK
5.3.2. Metal Nanoparticle as Photothermal Agent AM
5.3.3. Drug Release Triggered by Metal Nanoparticle-Based Hyperthermia AO
5.4. Upconversion Nanoparticles (UCNPs) AS
5.4.1. Imaging Agent AS
5.4.2. Photosensitizer Activator AS
5.5. Silica and Other Inorganic Nanomaterials AT
5.5.1. Silica AT
5.5.2. Calcium Phosphate AV
5.5.3. Apatite AV
5.5.4. Metal Organic Frameworks (MOFs) AV
5.6. Carbon-Based Nanomaterials AW
5.6.1. Carbon Nanomaterials as Carrier AW
5.6.2. Carbon Materials for Photothermal Therapy AY
6. Summary and Outlook AZ
Author Information BA
Corresponding Authors BA
Author Contributions BA
Notes BA
Biographies BA
Acknowledgments BB
Abbreviations BB
References BCChem. Rev.11.25ÐÂÏÊÉÏÏߣºNanomaterials for Theranostics: Recent Advances
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