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生物学中的表面分析技术（Surface Analysis and Techniques in Biology）
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Surface Analysis and Techniques in Biology The outer layer of bulk solid or liquid samples is referred to as the surface of the sample/material. At the surface, the composition, microstructure, phase, chemical bonding, electronic states, and/or texture is often different than that of the bulk material. The outer surface is where many material interactions/reactions take place. This is especially true biomaterials which may be fabricated into bio-devices and in turn implanted into tissues and organs. Surfaces of biomaterials (synthetic or modified natural materials) are of critical importance since the surface is typically the only part of the biomaterial/bio-device that comes in contact with the biological system. Analytical techniques are required to characterize the surface of biomaterials and quantify their impact in real-world biological systems. Surface analysis of biological materials started in the 1960’s and the number of researchers working in this area have increased very rapidly since then, a number of advances have been made to standard surface analytical instrumentation, and a number of new instruments have been introduced. We felt the time was right for a book which summarized the main surface analysis techniques that are being used to study biological specimens/systems. The compilation of chapters in this book will help the biological research community realize the benefits that surface analysis provides. We look forward to seeing a larger number of biologists and medical specialists using the techniques discussed in this book. It is of importance to note that new analysis instruments are continuously being developed and introduced to the scientific community – we look forward to seeing what the future has in store. We are also excited to see next generation medical devices, which will benefit from surface analysis, and which will help our society. About the Editor Vincent S. Smentkowski is a Senior Scientist in the Nanostructures and Surfaces Laboratory at General Electric Global Research (GEGR) where he performs surface analysis to support research programs at GEGR, GE businesses, and strategic partners. Currently, his research is focused on the applications of ToF-SIMS analysis, emphasizing how multivariate statistical analysis tools facilitate data reduction. Vin holds 6 U.S. patents, more than 85 publications in referred journals, greater than 100 GEGR internal manuscripts, has co-authored 3 book chapters, and has presented numerous contributed and invited talks. Vin is a Fellow of the American Vacuum Society. Table of contents : Content: Front Matter....Pages i-x Introduction....Pages 1-7 Applications of XPS in Biology and Biointerface Analysis....Pages 9-36 Biomolecular Analysis by Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS)....Pages 37-70 Cluster Secondary Ion Mass Spectrometry....Pages 71-98 Biological Tissue Imaging at Different Levels: MALDI and SIMS Imaging Combined....Pages 99-139 Molecular Structure and Identification Through G-SIMS and SMILES....Pages 141-170 Imaging with the Helium Ion Microscope....Pages 171-194 Sum Frequency Generation Vibrational Spectroscopy: A Sensitive Technique for the Study of Biological Molecules at Interfaces....Pages 195-224 Near-Field Scanning Optical Microscopy: A New Tool for Exploring Structure and Function in Biology....Pages 225-253 Atomic Force Microscopy: Applications in the Field of Biology....Pages 255-287 Multi-technique Characterization of DNA-Modified Surfaces for Biosensing and Diagnostic Applications....Pages 289-314 Back Matter....Pages 315-326 |
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