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Abstract Several new Cu(II) complexes of Schiff bases
obtained by condensation of 2-[N-(a-picolyl)-amino]-benzophenone with different chiral amino acids were synthesized
and characterized by physico-chemical and spectroscopic
methods. The crystal structure of one of the complexes was
determined using single crystal X-ray diffraction. The
ligands were coordinated to the metal atom in a tetradentate manner with ONNN donor sets using the carboxyl
oxygen, azomethine nitrogen, CON
-, and pyridine nitrogen. The cytotoxicities of the complexes were evaluated
against human cancer cells. The substituents on the aromatic rings strongly influenced the cytotoxicities of the
complexes. The complex with bromine substituents on the
pyridine rings showed the highest cytotoxicity. The antitumor activities against tumor cell lines were assayed in
vitro, and the complexes were found to be highly effective,
with six of the nine complexes having inhibition ratios
better than that of 5-Fluorouracil. This behavior is indicative of a high ability to circumvent the cellular drug
resistance mechanisms

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sudan789

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篮球少年: 金币+60, 翻译EPI+1, ★★★★★最佳答案, 很不错 2014-11-22 16:16:51
摘要:几种新的席夫碱类铜配合物经获得经带有不同的手性氨基酸的2- [氮-(A-吡啶甲基)-氨基] -二苯甲酮凝结法合成并用物理化学的和光谱的方法进行了表征。配合物的晶体结构采用单晶X射线衍射获得。配位体是以四配位基的方式配位到这金属原子上,onnn给体采用羧基氧、甲亚胺氮、CON-,和吡啶氮。评估了配合物对人类癌细胞的细胞毒性。苯环上的取代基上对这些配合物的细胞毒性有很强的影响。氮苯环上带有溴取代基的配合物显示出最强的细胞毒性。这种对肿瘤细胞系的抗癌试验是在试管内进行的,并且这些配合物被发现是卓有成效的、九种配合物中的六种比5-氟尿嘧啶有更好的抑制比。这一行为表现出一种较高的绕开细胞抗药性机构的能力。
事非经过不知难
2楼2014-11-21 18:10:38
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