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There are several approaches to promote tissue formation on scaffolds so that it can receive and respond to specific biological signals, which can direct and facilitate cell attachment, proliferation,differentiation and tissue regeneration [26]. Most of them took the idea of improving bioactivity by coating some proteins. For instance, Shen et al. immobilized rhBMP-2 on PLGA films via plasma treatment and found that the immobilized rhBMP-2 can stimulate the differentiation of OCT-1 cell and accelerate its mineralization [27]. Wang et al. immobilized collagen on PHBV surface by chemical treatment to improve chondrocytes compatibility[28]. However, numerous researchers found that micrometric topographies such as grooves and ridges can affect the cell responses because cells can orient themselves along the groove and ridge-so called ‘‘contact guidance’’ [29,30]. Surface topography on the macroscale can also affect tissues such as bone or cartilage significantly [31]. In this work, PHBV microspheres were embedded in a PLGA matrix in order to change the topological structure of the PLGA matrix and enhance the compressive strength of PLGA scaffold. The novel PLGA/PHBV scaffold was prepared using particle-leaching method. The diameters of PHBV microspheres were comparable with the thickness of PLGA matrix walls, which can change the topology of PLGA surface. The morphology, mechanical strength,pore parameters, and human mesenchymal stem cells (hMSCs) compatibility of the new scaffold were evaluated, as well as its ability to support hMSCs. Furthermore, the potential applications of new scaffold model were also discussed. |
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促进支架组织形成的方法有多种，如此支架可以接受和反应特定的生物信号，从而引导和促进细胞附着、增殖、分化和组织再生。大多数方法采用通过包裹某些蛋白质来增强生物活性。例如，Shen等通过等离子体处理在PLCA膜上固定rhBMP-2，他们发现固定的rhBMP-2可刺激OCT-1细胞的分化，并且加速器矿化。Wang等通过化学处理在PHBV表面固定胶原蛋白，以提高软骨细胞相容性。然而，许多研究者发现，微米级的形貌如和脊等可影响细胞反应性，这是因为细胞能沿着这些沟和脊定位自己——所谓的“接触引导”。宏观的表面形貌也能显著地影响骨或软骨组织。 在我们的工作中，PHBV微球包埋在PLGA基质中以改变PLGA基质的形貌结构以及增强PLGA支架的抗压强度。这种新型的ＰＬＧＡ／ＰＨＢＶ支架通过粒子洗出法来制备。ＰＨＢＶ微球的直径和ＰＬＧＡ的基质壁的厚度相当，从而可该表ＰＬＧＡ的表面形貌。我们评估了新支架的表观形貌、机械强度、孔参数和人类对ｈＭＳＣ干细胞的相容性，以及支架支撑ｈＭＳＣ干细胞的能力。同时，我们也对这种新型支架的潜在应用加以了讨论。 |
2楼2014-11-21 09:35:21