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Among them, amino acid (such as glycine,a-valine, balanine) Schiff bases and their first-row transition metal complexes were reported to exhibit antitumor activities [9– 16]. The clinical success of cisplatin in the treatment of several human malignant tumors was motivated major research efforts toward the discovery of alternative metal complexes with potential as anticancer drugs [17, 18]. So far, some of the most promising results have been reported for copper, which exhibits antitumor activity even in the form of simple copper(II) salts [19].  4.jpg |
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