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肾脏中出现治疗相关的作用。特别是发现肾小管变性/再生的发病率和严重程度有剂量依赖性。 These lesions occurred mainly in the tubules and ducts in the medullary rays and varied in severity from minimal to moderate. The change exhibited mainly as a swelling of the cytoplasm of the tubular epithelial cells with occasiona1 apoptosis and some loss of nuclear staining.Regenerative hyperp1asia of epithelial cells was observed, particularly in more severely affected animals. Tubular degeneration/ regeneration was present diffusely in al1 or most of the medullary rays in some animals and in occasional foci in others. interstitial edema (primarily in the medulla) was observed in some of the more severely affected animals , possibly suggesting an alteration in tubular function. |
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4楼2014-10-22 11:55:13
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2楼2014-10-22 11:05:48
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3楼2014-10-22 11:13:05
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5楼2014-10-22 11:59:01
