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chemical reviews10.20 新鲜在线：“Recycling” Classical Drugs for Malaria
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“Recycling” Classical Drugs for Malariags for Malaria Cátia Teixeira,*,†, ‡ Nuno Vale,† Bianca Pérez,† Ana Gomes,† José R. B. Gomes, ‡ and Paula Gomes*,† （57页271篇参考文献）看题目就有新意，值得研读  1.jpg CONTENTS 1. Introduction A 2. Chemical Recycling of Quinine: The Rise of Emblematic 20th Century Antimalarials B 2.1. Quinine: Past, Present and Future B 2.2. Quinine and the Birth of Major 20th Century Antimalarial Drug Classes D 3. Antimalarial 8-Aminoquinolines: Still Seeking for a Suitable Substitute of Primaquine D 3.1. From Pamaquine to Primaquine——Targeting Parasite’s Liver and Sexual Stages D 3.2. Primaquine-Based 8-Aminoquinolines in Specific Clinical Settings or under Clinical Trials D 3.3. Recycling Primaquine: Toward Novel Antimalarial 8-Aminoquinolines F 3.3.1. Modifications Exclusively at the Aliphatic Chain of Primaquine F 3.3.2. Modifications Involving the Quinoline Ring in Primaquine H 3.3.3. Dual-Core Hybrids I 4. Antimalarial Acridines: Revival of Quinacrine, The First Synthetic Blood-Stage Antimalarial K 4.1. Acridine-Inspired Antimalarial Leads: Acridones and Related Structures L 4.2. Revival of Quinacrine and Pyronaridine: In Pursuit of Next Generation Antimalarial Amino- and Aniline-Acridines N 4.2.1. 9-Aminoacridine Leads N 4.2.2. 9-Anilinoacridine Leads O 4.2.3. Organometallic Leads P 4.2.4. Quinacrine Hybrids Q 5. Antimalarial 4-Aminoquinolines: Keeping Track on 21st Century Chloroquine Surrogates R 5.1. Historical Synopsis of Clinically Relevant Antimalarial 4-Aminoquinolines R 5.2. Current Chloroquine-Inspired Antimalarial Leads S 5.2.1. Chloroquine-Based Compounds S 5.2.2. Amodiaquine-Based Compounds X 5.2.3. Piperaquine-Inspired Compounds Z 5.2.4. Organometallic 4-Aminoquinolines AA 5.2.5. 4-Aminoquinoline Hybrids AB 6. Computational Studies on Antimalarial Classics and Their Analogues AH 6.1. Targeting Inhibition of Hemozoin Formation AI 6.2. Aiming at Inhibition of Other Parasitic Targets AM 6.3. Investigating Possible Mechanisms of Drug Toxicity AO 7. Rescuing and Repurposing Drugs for Malaria AP 7.1. Antitumorals AQ 7.2. Antiretrovirals AU 8. Final Remarks AV Author Information AV Corresponding Authors AV Notes AV Biographies AW Acknowledgments AX Abbreviations AX References AX |
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2014-10-22 09:18:20, 2.65 M
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