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guojingtao

铁虫 (小有名气)

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注册: 2008-09-18
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专业: 色谱分析

[求助] 懂临床医学的帮看看这段文字是啥意思？

Stroke or systemic embolism occurred in 182 patients receiving 110 mg of dabigatran (1.53% per year), 134 patients receiving 150 mg of dabigatran (1.11% per year), and 199 patients receivingwarfarin (1.69% per year) (Table 2 and Fig. 1). Both doses of dabigatran were noninferior to warfarin (P<0.001). The 150-mg dose of dabigatran was also superior to warfarin (relative risk, 0.66; 95% confidence interval [CI], 0.53 to 0.82; P<0.001), but the 110-mg dose was not (relative risk, 0.91; 95%CI, 0.74 to 1.11; P = 0.34). Rates of hemorrhagic stroke were 0.38% per year in the warfarin group, as compared with 0.12% per year in the group that received 110 mg of dabigatran (relative risk with dabigatran, 0.31; 95% CI, 0.17 to 0.56; P<0.001) and 0.10% per year in the group that received 150 mg of dabigatran (relative risk, 0.26; 95% CI, 0.14 to 0.49; P<0.001).
上面这段话有谁能帮我讲讲，The 150-mg dose of dabigatran was also superior to warfarin (relative risk, 0.66; 95% confidence interval [CI], 0.53 to 0.82; P<0.001)这句话中0.66,95%，0.53-0.82、p都是什么含义？通过这个可看出达比加群酯全身性栓塞发生率低于华法林么？relative risk是什么意思？In this noninferiority trial, 文章中提到了非劣效性试验，是不是只做非劣效性试验就可以证明药物的有效性？

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