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1.One goal in our studies is the synthesis of new {5-deaza-and8-deazapteridines} as folate antagonists. 2.b-dicarbonyl derivatives or a,b-unsaturated aldehydes, were cyclocondensated with different {1,3-bisnucleophiles} , e.g., cyanacetamide(7)or pyrimidine-2,4,6-triamine(14). 3.12was than treated with dimethylformamideand phosphoroxychloride under mild conditions and furtherwithN,N-dimethylammoniumperchlorate to yield the {trime-thinium perchlorate} 13, representing a reactive derivative ofmalondialdehyde[19]. 4.Recently an alternative preparation of Nor-PTX(3)has been published by condensation14and { bromomalondialdehyde} ,followed by protection of amino groups and Pd-mediated coupling with 2,5-dimethoxybenzyl zinc chloride and final deprotection of the pivaloylated aminogroups[16](Fig. 3) 5. Treatment with dimethylformamide, phos-phoroxychloride and crystallisation with {N,N-dimethyl am-monium per chlorate} gave { trimethinium }salt24 6.{Before methotrexate can act as an antitumor agent, an active transport mechanisms into the cell and polyglutamation by the enzyme folypoly-glutamate synthase is necessary.} 7.{Pneumocystis cariniiandToxoplasma gondii} Òâ˼´óÀ¨ºÅµÄ´Ê»ò¾ä£¬Ã¿¸ö±àºÅ¶¼ÊÇÒ»¾ä»°£¬ÎªÁ˸üÇå³þµÄ¿´µ½Òª·ÒëµÄ´Ê£¬ËùÒÔ¶Ï¿ª¡£ ¸Ðл |
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2Â¥2014-10-08 00:10:37
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3Â¥2014-10-08 08:11:53
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4Â¥2014-10-08 11:25:31
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