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In mice, mortality, severity and incidence of neurotoxicity and leukopenia occurred at cumulative dose levels which were comparable to the corresponding single-dose levels , e .g. the cumulative 5-day LD50 was 450 mg/ m2£¨5x 90 mg m2) which correlates well with the single-dose LD50 of 414 mg/ m2. In dogs, gastrointestinal toxicity and leukopenia of cumulative daily doses were of a severity corresponding to comparable single-dose levels: five daily doses of 6 mg/m2 produced adverse effects comparable to those following a single dose of 30 mg/m2. |
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