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ÊéÃû Binding, Transport and Storage of Metal Ions in Biological Cells ×÷ÕßWolfgang Maret Ò³Êý938 ³ö°æÉç RSC ISBN: 978-1-84973-599-5 eISBN: 978-1-84973-997-9 Chapter 1 Overview 1 Robert J. P. Williams References 5 Chapter 2 Sodium. Its Role in Bacterial Metabolism 6 Masahiro Ito and Blanca Barquera 2.1 Sodium Ions in Nature 6 2.1.1 The Coordination Chemistry of the Sodium Ion 7 2.1.2 Small Molecule Ligands 7 2.2 Sodium versus Hydrogen Ions in Bacteria 7 2.2.1 The Sodium Ion Gradient as a Distributed Power Source 8 2.3 Co-transport of Nutrients Using Sodium Ions 9 2.4 Role of Sodium/Proton Antiporters 10 2.4.1 Role of Sodium/Proton Antiporters at Alkaline pH 11 2.4.2 The Sodium/Proton Antiporter Activity of Mrp 11 2.5 Generation of Sodium Ion Gradients 14 2.5.1 Redox-driven Sodium Ion Pumps 14 2.5.2 Decarboxylases that Pump Sodium Ions 18 2.5.3 The Sodium Ion-translocating Methyl Transferase from Methanogenic Archaea 20 2.6 The Sodium Ion-translocating ATPase/ATP Synthase 20 2.6.1 ATPase as a Rotary Motor 20 2.6.2 Structure of the Sodium Ion-translocating V-ATPase 21 RSC Metallobiology Series No. 2 Binding, Transport and Storage of Metal Ions in Biological Cells Edited by Wolfgang Maret and Anthony Wedd r The Royal Society of Chemistry 2014 Published by the Royal Society of Chemistry, www.rsc.org ix Downloaded on 24/07/2014 09:38:10. Published on 09 July 2014 on http://pubs.rsc.org | doi:10.1039/9781849739979-FP009 2.6.3 Sodium Ion Binding Site in the K Ring 22 2.6.4 The Sodium Ion-translocating F-ATPase from Polyextremophilic Natranaerobius thermophilus 22 2.6.5 The ATP Synthase in Methanosarcina acetivorans is Driven by a Proton and a Sodium Ion Gradient 24 2.6.6 Future Prospects 24 2.7 A Voltage-gated Sodium Ion Channel, NaChBac 24 2.7.1 The Physiological Roles of NaChBac in Bacteria 25 2.7.2 Localization of NaChBac in the Cell 28 2.8 Sodium Ion-coupled Flagellar Motility 29 2.8.1 Bacterial Flagellar Motor 30 2.8.2 Proton-coupled Flagellar Motors 31 2.8.3 Sodium Ion-coupled Flagellar Motor 31 2.8.4 Dual Motility Systems of Bacterial Flagellar Motors 32 2.8.5 Proposed Mechanisms of Bacterial Flagellar Rotation 32 2.8.6 The Energy Source for the Flagellar Stator Protein from Alkaliphilic Bacteria 33 2.9 Final Remarks 33 References 35 Chapter 3 Potassium 43 David M. Miller and Jacqueline M. Gulbis 3.1 Eukaryotes 43 3.1.1 Introduction 43 3.1.2 Uptake and Excretion 50 3.1.3 Coordination Chemistry of the Ion in the Blood 54 3.1.4 Transport through Membranes 55 3.1.5 Sensing, Buffering and other Control Mechanisms (Cellular Homeostasis) 62 3.1.6 Conclusions 69 (RSC Metallobiology) Wolfgang Maret, Anthony Wedd, Anthony Wedd, C David Ga.jpg w.jpg ÎÊÎÊ.jpg |
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