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专业: 无机药物化学

[求助] 求助一句话翻译

结果：哌甲酯在中等剂量下（1.0–2.0 mg/kg，p.o.）显著改善延迟交替任务中的表现，出现了一条倒U剂量效应曲线，而更高剂量（2.0–3.0 mg/kg, p.o.）组的动物出现很多持续性错误。哌甲酯的改善表现作用被α2受体拮抗剂咪唑克生或多巴胺D1拮抗剂SCH23390阻断，in doses that had no effect on their own.

原文 Results: MPH produced an inverted U dose response whereby moderate doses (1.0–2.0 mg/kg,
p.o.) significantly improved delayed alternation performance, while higher doses (2.0–3.0 mg/kg,
p.o.) produced perseverative errors in many animals. The enhancing effects of MPH were blocked
by co-administration of either the α2 adrenoceptor antagonist, idazoxan, or the dopamine D1
antagonist, SCH23390, in doses that had no effect on their own.

in doses that had no effect on their own.是什么意思

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