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ÊéÃûCannabinoids
×÷ÕßVincenzo Di Marzo
Institute of Biomolecular Chemistry
Consiglio Nazionale delle Ricerche
Pozzuoli, Italy
Ò³Êý320
³ö°æÉç wiley
Contents
List of Contributors xiii
Preface xv
1 Looking ahead after 50 years of research on cannabinoids 1
Raphael Mechoulam
1.1 Summary 1
1.2 Introduction 1
1.3 Cannabidiol (CBD) 6
1.4 Fatty acid amides of amino acids and related compounds 8
1.5 Conclusions 10
1.6 References 10
2 Cannabinoid receptor intracellular signalling: The long
journey from binding sites to biological effects 17
Lawrence C. Blume, Khalil M. Eldeeb and Allyn C. Howlett
2.1 Historical progression: Serendipity to opportunity 18
2.2 Significance of being a G protein coupled receptor (GPCR) 21
2.3 CB1 cannabinoid receptor interactions with other cellular signals 23
2.4 Functional role of CB1 receptor accessory proteins 25
2.5 Opportunities: Pharmacotherapeutic insights based on cell signalling 33
2.6 Concluding remarks 41
2.7 References 41
3 Endocannabinoid biochemistry:What do we know after
50 years? 53
Filomena Fezza and Mauro Maccarrone
3.1 Introduction 54
3.2 Endocannabinoids and related molecules 60
3.3 Biosynthesis of endocannabinoids and related molecules 66
3.4 Degradation of endocannabinoids 71
3.5 Oxidative metabolism of endocannabinoids 77
3.6 Conclusions and future perspectives 78
3.7 References 83¡ï¡ï¡ï¡ï¡ï¡ï2014Êé¼®³¬¼¶ÌûÁùÁù°Ë¡¶´óÂé¡·2014 wiley×îÐÂÊé¼®
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