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Springer-Nasopharyngeal Carcinoma:Keys for Translational Medicine and Biology
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鼻咽癌：转化医学和生物学的钥匙Nasopharyngeal Carcinoma: Keys for Translational Medicine and Biology Pierre Busson Université Paris‑Sud 11, CNRS and Institut de Cancérologie Gustave Roussy Villejuif, France About this Book Although listed as a rare cancer in a majority of countries, Nasopharyngeal carcinoma (NPC) has a high incidence and appears as a serious public health problem in several highly populated areas of Southeast Asia and to a lesser extent in North Africa. Worldwide, its incidence rates at 85,000 new cases per year (Globocan 2008). Thus, in terms of incidence, among human virus-associated cancers, NPC ranks third behind liver and cervix carcinoma (750,000 and 530,000, respectively). In 2008, the mortality rate of NPC was still about 51,000 per year worldwide (Globocan). NPC is a multifactorial disease related to dietary, viral and genetic factors. Despite fascinating biological characteristics, NPC has long been aside from the mainstream of cancer research for both scientific and socio-economical reasons. It is noteworthy that biological investigations have long been hampered by the paucity of laboratory models and the lack of data on premalignant states. However, recently, in several high incidence countries, strong economic growth and rapid progress in health care has propelled NPC on the front stage of cancer research, worldwide. Simultaneously, in other places, the identification of Head and Neck cancers associated to human papilloma viruses has renewed interest for NPC as a proxy model of viral carcinogenesis. As explained in the title, this book intends to contribute to “translational medicine and biology”. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties. This is precisely the aim of the twelve chapters of this book. It will be useful for scientists, including PhD students, who want to become more familiar with the main concepts of NPC pathology, medical imaging and current therapeutics. Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis.  bi.png  zuozhe.png |
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2014-07-25 14:29:31, 6.59 M
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2015-08-19 22:25
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