| 查看: 1661 | 回复: 1 | |||
[交流]
gliosis和glioma有什么区别？ 已有1人参与
|
|
查了些文献都没有谈清楚，有大神指点一下嘛 gliosis指胶质增生，glioma是胶质瘤，但是有时候又不太能分清楚。 |
回复此楼» 猜你喜欢
论文终于录用啦！满足毕业条件了
已经有27人回复
-
假如你的研究生提出不合理要求
已经有3人回复
-
所感
已经有3人回复
-
要不要辞职读博？
已经有7人回复
-
不自信的我
已经有11人回复
-
北核录用
已经有3人回复
-
实验室接单子
已经有3人回复
-
磺酰氟产物，毕不了业了！
已经有8人回复
-
求助:我三月中下旬出站，青基依托单位怎么办？
已经有10人回复
-
26申博（荧光探针方向，有机合成）
已经有4人回复
zirow
木虫 (小有名气)
- 应助: 2 (幼儿园)
- 金币: 3751.8
- 红花: 3
- 帖子: 82
- 在线: 234.8小时
- 虫号: 1924189
- 注册: 2012-08-04
- 性别: MM
- 专业: 金融学
|
Gliosis versus glioma?: don't grade until you know. Marie Rivera-Zengotita Anthony T Yachnis Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, USA. Advances in anatomic pathology (Impact Factor: 3.22). 07/2012; 19(4):239-49. DOI: 10.1097/PAP.0b013e31825c6a04 Source: PubMed ABSTRACT A major challenge in the routine practice of surgical neuropathology is the distinction between reactive astrocytosis, which may be because of non-neoplastic and neoplastic conditions, and a low-grade infiltrating diffuse astrocytoma [World Health Organization (WHO) grade II]. This can be particularly challenging with small biopsies that often yield limited amounts of tissue for pathologic study, especially considering the marked differences in prognosis and therapy after a pathologic diagnosis. This paper will review some basic principles of gliosis as an astrocytic reaction to a wide range of central nervous system insults and focus on some common diagnostic pitfalls such as (1) gliosis associated with brain tumor mimics, including demyelinating disease and infections, (2) gliosis associated with nonglial tumors such as craniopharyngioma, hemangioblastoma, metastases, and central nervous system lymphoma. New diagnostic methods have facilitated the differentiation between reactive astrocytosis and the diffuse gliomas. Of these, the use of mutated isocitrate dehydrogenase-1 (IDH-1) as a marker of diffuse infiltrating astroctomas, oligodendrogliomas, and a subset of glioblastomas (secondary glioblastomas) is particularly exciting for tissue diagnosis and patient prognosis. In addition IDH-1 may be useful to distinguish a diffuse infiltrating glioma from low-grade "focal" neoplasms such as the pilocytic astocytoma in histologically ambiguous cases. The discovery of BRAF mutations as molecular signatures of some pilocytic astrocytomas, gangliogliomas, and pleomorphic xanthoastrocytomas has provided another diagnostic tool for the pathologist. Only after a definitive diagnosis of a diffuse infiltrating glioma or a focal glioma is made should a tumor grade be applied and some practical issues in current glioma grading are provided. |
2楼2014-07-24 09:58:35