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[资源] ★★★★★★★2014书籍超级帖四四一《生物医药超分子系统》高清英文书籍

书名Supramolecular Systems in Biomedical Fields
作者Hans-Jo¨ rg Schneider
Saarland University, Saarbru¨cken, Germany
Email: h-j.schneider@mx.uni-saarland.de
页数548
出版社Royal Society of Chemistry
ISBN: 978-1-84973-658-9
ISSN: 1368-8642
目录Contents
Chapter 1 Introduction 1
Hans-Jo¨rg Schneider
1.1 Sensing/Diagnostics/Imaging 2
1.2 Interaction with Proteins and Nucleic Acids 3
1.3 Drug Protection, Release and Targeting, Gene Delivery 4
References 5
Chapter 2 Signalling Techniques in Supramolecular Systems 7
Jealemy Galindo Milla′n and Leonard J. Prins
2.1 Introduction 7
2.1.1 Background 7
2.1.2 Signal Amplification in Nature 8
2.1.3 Biological Assays 9
2.1.4 Signalling Strategies in Synthetic Systems 9
2.2 DNA Detection 10
2.2.1 Catalysis 10
2.2.2 Multivalency 13
2.2.3 Catalysis and Multivalency 18
2.3 Small (bio)Molecule Detection 19
2.3.1 Catalysis 19
2.3.2 Multivalency 23
2.4 Protein Detection 29
2.4.1 Catalysis 29
2.4.2 Multivalency 32
2.5 Conclusions 34
Acknowledgement 34
References 34
Monographs in Supramolecular Chemistry No. 13
Supramolecular Systems in Biomedical Fields
Edited by Hans-Jo¨ rg Schneider
r The Royal Society of Chemistry 2013
Published by the Royal Society of Chemistry, www.rsc.org
vii
.
Published on 31 October 2013 on http://pubs.rsc.org | doi:10.1039/9781849737821-FP007
Chapter 3 Metal Ion Sensing for Biomedical Uses 38
David C. Magri and Carl J. Mallia
3.1 Introduction 38
3.2 Sensing Mechanisms 40
3.2.1 Photoinduced Electron Transfer (PET) 40
3.2.2 The State-of-the-Art in Point-of-Care
Technology 41
3.3 Alkali and Alkaline Earth Ion Chemosensors 42
3.3.1 Sodium (Na1) 43
3.3.2 Potassium (K1) 45
3.3.3 Calcium (Ca21) 47
3.3.4 Magnesium (Mg21) 48
3.3.5 Lithium (Li1) 49
3.4 Heavy Metal Ion Chemosensors 51
3.4.1 Iron (Fe31) 51
3.4.2 Zinc (Zn21) 53
3.4.3 Copper (Cu1 and Cu21) 55
3.4.4 Mercury (Hg21), Cadmium (Cd21) and
Lead (Pb21) 56
3.5 Actinide and Lanthanide Ion Chemosensors 58
3.6 Strategies for Multi-Analyte Sensing 59
3.6.1 ‘Lab-on-a-Molecule’ Systems 59
3.6.2 One Receptor for Multiple Analytes 61
3.7 Summary and Outlook 62
Acknowledgements 62
References 63
Chapter 4 Complexation of Biomedically Important Organic
Compounds 68
Hans-Jo¨rg Schneider
4.1 Introduction 68
4.2 Amines/Neurotransmitters/Catecholamines 69
4.3 Biologically Important Acids 73
4.3.1 Amino Acids 74
4.4 Peptides 75
4.5 Nucleotides 77
4.6 Ureas, Biotin and Barbiturates 81
4.7 Carbohydrates 82
4.8 Steroids, Bile Acids, Prostaglandins 85
4.9 Alkaloids 86
4.10 Antibiotics and Toxins 87
Acknowledgement 88
References 88
viii Contents
.
Published on 31 October 2013 on http://pubs.rsc.org | doi:10.1039/9781849737821-FP007
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2014-06-17 13:59:52, 19.49 M