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小木虫论坛-学术科研互动平台 » 生物医药区 » 药学 » 天然药物化学 » ★★★★★★★2014书籍超级帖三七九《植物生物制药》高清英文书籍
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[资源] ★★★★★★★2014书籍超级帖三七九《植物生物制药》高清英文书籍

书名Biopharmaceuticals
in Plants
作者KATHLEEN LAURA HEFFERON
页数 230
出版社 crc press
ISBN-13: 978-1-4398-0474-2 (hardcover : alk. paper)
目录Contents
Preface.....................................................................................................xiii
Acknowledgments.................................................................................... xv
The Author............................................................................................. xvii
Chapter 1 History of Plants in Production of Biopharmaceuticals........ 1
1.1 Introduction................................................................. 1
1.2 History of Vaccine Development................................. 2
1.3 History of Vaccine Proteins Produced in Plants.......... 3
1.4 Transformation of Plant Tissue.................................... 5
1.5 Agrobacterium tumefaciens-Mediated Plant
Transformation............................................................ 6
1.5.1 History and Concept of Agrobacterium
tumefaciens for Plant Transformation............. 6
1.5.2 Molecular Basis of Agrobacterium-
Mediated Transformation................................ 7
1.5.3 Vir Proteins Used in Agrobacterium-
Mediated Transformation................................ 9
1.5.3.1 VirA and VirG Proteins.................... 9
1.5.3.2 VirD4 and VirB Proteins................... 9
1.5.3.3 VirD2 and VirE2 Proteins................10
1.5.3.4 VirF Protein......................................11
1.5.4 Other Genes That Play a Role in
Agrobacterium-Mediated Transformation..... 12
1.5.5 Integration of T-DNA into the Host
Genome..........................................................13
1.5.6 Host Range and Susceptibility of Plants
to Agrobacterium Transformation..................13
1.6 Other Transformation Techniques..............................14
1.6.1 Biolistic Delivery............................................14
1.6.2 Polyethylene Glycol (PEG) and Other
Transformation Methods............................... 15
1.7 Problems Associated with Transformation
Techniques................................................................. 15
1.8 Transformation of Cereals..........................................16
1.9 Hairy Root Transformation........................................17
1.10 Selectable Marker Genes............................................17
1.11 Regulation of Transgene Expression..........................18
vi Contents
1.11.1 Promoter and Terminator Elements................18
1.11.2 Constitutive Promoters...................................18
1.11.2.1 35S CaMV Promoter........................18
1.11.2.2 Ubi1 Promoter..................................19
1.11.3 Plant Viral Leader Sequences.........................19
1.11.4 Chemical-Inducible and Developmental
Promoters for Temporal or Spatial Gene
Expression......................................................19
1.11.5 Construction of Synthetic Genes....................21
1.11.6 Targeting of Protein to Plant Cell
Organelles.......................................................21
1.11.7 Transgenic Plants and Gene Silencing............21
1.12 Conclusions................................................................ 23
References........................................................................... 23
Chapter 2 Transgenic Plants Expressing Vaccine and Therapeutic
Proteins................................................................................ 27
2.1 Introduction............................................................... 27
2.2 Transgenic Plants Expressing Vaccines against
Diarrheal Diseases..................................................... 28
2.2.1 LT-B and CT-B.............................................. 28
2.2.2 Norwalk Virus............................................... 30
2.2.3 Rotavirus........................................................31
2.2.4 Hepatitis B Virus (HBV)................................31
2.2.5 Tuberculosis (TB)...........................................33
2.2.6 Human Immunodeficiency Virus (HIV)........33
2.2.7 Plague Vaccine...............................................33
2.2.8 Measles Virus................................................ 34
2.2.9 Papillomavirus............................................... 34
2.2.10 Smallpox Virus.............................................. 35
2.2.11 Influenza Virus.............................................. 36
2.3 Animal Vaccines Produced in Plants........................ 36
2.3.1 Foot and Mouth Disease Virus...................... 36
2.3.2 Bovine Rotavirus........................................... 37
2.3.3 Transmissible Gastroenteritis Virus.............. 37
2.3.4 Infectious Bursal Disease Virus.................... 37
2.3.5 Newcastle Disease Virus............................... 38
2.3.6 Rabbit Hemorrhagic Disease Virus
(RHDV)......................................................... 38
2.3.7 Canine Parvovirus (CPV).............................. 38
2.4 The Use of Antibodies in Plants as
Immunotherapeutic Agents....................................... 39
Contents vii★★★★★★★2014书籍超级帖三七九《植物生物制药》高清英文书籍
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