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★★★★★★★2014书籍超级帖三七九《植物生物制药》高清英文书籍
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书名Biopharmaceuticals in Plants 作者KATHLEEN LAURA HEFFERON 页数 230 出版社 crc press ISBN-13: 978-1-4398-0474-2 (hardcover : alk. paper) 目录Contents Preface.....................................................................................................xiii Acknowledgments.................................................................................... xv The Author............................................................................................. xvii Chapter 1 History of Plants in Production of Biopharmaceuticals........ 1 1.1 Introduction................................................................. 1 1.2 History of Vaccine Development................................. 2 1.3 History of Vaccine Proteins Produced in Plants.......... 3 1.4 Transformation of Plant Tissue.................................... 5 1.5 Agrobacterium tumefaciens-Mediated Plant Transformation............................................................ 6 1.5.1 History and Concept of Agrobacterium tumefaciens for Plant Transformation............. 6 1.5.2 Molecular Basis of Agrobacterium- Mediated Transformation................................ 7 1.5.3 Vir Proteins Used in Agrobacterium- Mediated Transformation................................ 9 1.5.3.1 VirA and VirG Proteins.................... 9 1.5.3.2 VirD4 and VirB Proteins................... 9 1.5.3.3 VirD2 and VirE2 Proteins................10 1.5.3.4 VirF Protein......................................11 1.5.4 Other Genes That Play a Role in Agrobacterium-Mediated Transformation..... 12 1.5.5 Integration of T-DNA into the Host Genome..........................................................13 1.5.6 Host Range and Susceptibility of Plants to Agrobacterium Transformation..................13 1.6 Other Transformation Techniques..............................14 1.6.1 Biolistic Delivery............................................14 1.6.2 Polyethylene Glycol (PEG) and Other Transformation Methods............................... 15 1.7 Problems Associated with Transformation Techniques................................................................. 15 1.8 Transformation of Cereals..........................................16 1.9 Hairy Root Transformation........................................17 1.10 Selectable Marker Genes............................................17 1.11 Regulation of Transgene Expression..........................18 vi Contents 1.11.1 Promoter and Terminator Elements................18 1.11.2 Constitutive Promoters...................................18 1.11.2.1 35S CaMV Promoter........................18 1.11.2.2 Ubi1 Promoter..................................19 1.11.3 Plant Viral Leader Sequences.........................19 1.11.4 Chemical-Inducible and Developmental Promoters for Temporal or Spatial Gene Expression......................................................19 1.11.5 Construction of Synthetic Genes....................21 1.11.6 Targeting of Protein to Plant Cell Organelles.......................................................21 1.11.7 Transgenic Plants and Gene Silencing............21 1.12 Conclusions................................................................ 23 References........................................................................... 23 Chapter 2 Transgenic Plants Expressing Vaccine and Therapeutic Proteins................................................................................ 27 2.1 Introduction............................................................... 27 2.2 Transgenic Plants Expressing Vaccines against Diarrheal Diseases..................................................... 28 2.2.1 LT-B and CT-B.............................................. 28 2.2.2 Norwalk Virus............................................... 30 2.2.3 Rotavirus........................................................31 2.2.4 Hepatitis B Virus (HBV)................................31 2.2.5 Tuberculosis (TB)...........................................33 2.2.6 Human Immunodeficiency Virus (HIV)........33 2.2.7 Plague Vaccine...............................................33 2.2.8 Measles Virus................................................ 34 2.2.9 Papillomavirus............................................... 34 2.2.10 Smallpox Virus.............................................. 35 2.2.11 Influenza Virus.............................................. 36 2.3 Animal Vaccines Produced in Plants........................ 36 2.3.1 Foot and Mouth Disease Virus...................... 36 2.3.2 Bovine Rotavirus........................................... 37 2.3.3 Transmissible Gastroenteritis Virus.............. 37 2.3.4 Infectious Bursal Disease Virus.................... 37 2.3.5 Newcastle Disease Virus............................... 38 2.3.6 Rabbit Hemorrhagic Disease Virus (RHDV)......................................................... 38 2.3.7 Canine Parvovirus (CPV).............................. 38 2.4 The Use of Antibodies in Plants as Immunotherapeutic Agents....................................... 39 Contents vii  Kathleen Laura Hefferon-Biopharmaceuticals in Plants_ Toward the Next Centu.jpg |
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