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The efficacy and toxicity of drug is closely related to its biotransformation in vivo. Pharmacokinetic study can not only describe the varying pattern of drugs in animals and human body, but also guide the design and selection of lead compound, optimize the administration route, and improve the dosage form in the process of new drug development. In this study, HgCl2 and CCl4 were used respectively to establish the ARF-rabbit and ALI-rabbit model, in which the research was carried out on the pharmacokinetics of sulfadiazine under the condition of liver and kidney impairment .