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Acc. Chem. Res.最新综述：RNA自组装与RNA纳米技术
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RNA Self-Assembly and RNA Nanotechnology Wade W. Grabow* ,† and Luc Jaeger* ,‡ †Department of Chemistry and Biochemistry, Seattle Paci fi c University, 3307 Third Avenue West, Seattle, Washington 98119, United States ‡ Department of Chemistry and Biochemistry, Bio-Molecular Science and Engineering Program, University of California, Santa Barbara, California 93106-9510, United States CONSPECTUS: Nanotechnology ’ s central goal involves the direct control of matter at the molecular nanometer scale to build nanofactories, nanomachines, and other devices for potential applications including electronics, alternative fuels, and medicine. In this regard, the nascent use of nucleic acids as a material to coordinate the precise arrangements of speci fi c molecules marked an important milestone in the relatively recent history of nanotechnology. While DNA served as the pioneer building material in nucleic acid nanotechnology, RNA continues to emerge as viable alternative material with its own distinct advantages for nanoconstruction. Several complementary assembly strategies have been used to build a diverse set of RNA nanostructures having unique structural attributes and the ability to self-assemble in a highly programmable and controlled manner. Of the di ff erent strategies, the architectonics approach uniquely endeavors to understand integrated structural RNA architectures through the arrangement of their characteristic structural building blocks. Viewed through this lens, it becomes apparent that nature routinely uses thermodynamically stable, recurrent modular motifs from natural RNA molecules to generate unique and more complex programmable structures. With the design principles found in natural structures, a number of synthetic RNAs have been constructed. The synthetic nanostructures constructed to date have provided, in addition to a ff ording essential insights into RNA design, important platforms to characterize and validate the structural self-folding and assembly properties of RNA modules or building blocks. Furthermore, RNA nanoparticles have shown great promise for applications in nanomedicine and RNA-based therapeutics. Nevertheless, the synthetic RNA architectures achieved thus far consist largely of static, rigid particles that are still far from matching the structural and functional complexity of natural responsive structural elements such as the ribosome, large ribozymes, and riboswitches. Thus, the next step in synthetic RNA design will involve new ways to implement these same types of dynamic and responsive architectures into nanostructures functioning as real nanomachines in and outside the cell. RNA nanotechnology will likely garner broader utility and in fl uence with a greater focus on the interplay between thermodynamic and kinetic in fl uences on RNA self-assembly and using natural RNAs as guiding principles.  |
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