24小时热门版块排行榜

>论坛更新日志 (4576)
>休闲灌水 (475)
>虫友互识 (388)
>导师招生 (339)
>文献求助 (327)
>论文投稿 (186)
>博后之家 (173)
>招聘信息布告栏 (134)
>硕博家园 (65)
>学术会议 (63)
>考博 (56)
>找工作 (43)
>基金申请 (40)
>教师之家 (34)
>育儿交流 (33)
>有机交流 (30)

返回列表

当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖

liulud

金虫 (正式写手)

应助: 1 (幼儿园)
金币: 630.9
帖子: 310
在线: 23.8小时
虫号: 652130

[交流] JACS文章被封推，散100金币

Highly Site-Selective Direct C–H Bond Functionalization of Phenols with α-Aryl-α-diazoacetates and Diazooxindoles via Gold Catalysis
Zhunzhun Yu , Ben Ma , Mingjin Chen , Hai-Hong Wu , Lu Liu *, and Junliang Zhang *
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China

J. Am. Chem. Soc., 2014, 136 (19), pp 6904–6907
DOI: 10.1021/ja503163k
Publication Date (Web): April 29, 2014
Copyright © 2014 American Chemical Society
*E-mail: lliu@chem.ecnu.edu.cn., *E-mail: jlzhang@chem.ecnu.edu.cn.
Section:
General Organic Chemistry

Abstract

An unprecedented direct C–H bond functionalization of unprotected phenols with α-aryl α-diazoacetates and diazooxindoles was developed. A tris(2,4-di-tert-butylphenyl) phosphite derived gold complex promoted the highly chemoselective and site-selective C–H bond functionalization of phenols and N-acylanilines with gold-carbene generated from the decomposition of diazo compounds, furnishing the corresponding products in moderate to excellent yields at rt. The salient features of this reaction include readily available starting materials, unprecedented C–H functionalization rather than X–H insertion, good substrate scope, mild conditions, high efficiency, and ease in further transformation. To the best of our knowledge, this is the first example of C–H functionalization of unprotected phenols with diazo compounds.

http://pubs.acs.org/doi/abs/10.1021/ja503163k

jacs503163k.jpg

回复此楼