| 查看: 360 | 回复: 0 | |||
cainiaodui新虫 (小有名气)
|
[求助]
翻译求助
|
|
The microenvironmental abundance of VEGF and other proangiogenic factors drives continual angiogenesis and the production of an abnormal blood vessel network. Structurally, vessels are often dilated, weave a tortuous path, and show heterogeneity of distribution such that certain areas within a tumor are hypovascular and others hypervascular. At the cellular level, proangiogenic factors induce weakening of VE-Cadherin-mediated endothelial cell (EC) junctions and EC migration, altering vessel wall architecture. Similarly, the perivascular cells (PVCs, comprised of pericytes and vascular smooth muscle cells [VSMCs]) are often only loosely attached to ECs and are reduced in number. A number of important molecules regulate pericyte– EC interaction, including platelet-derived growth factor-B (PDGF-B), Ang-1, transforming growth factor-b(TGF-b), and sphingosine-1-phosphate (S1P) in healthy tissues. In tumors, proangiogenic factors promote PVCEC dissociation, however. For example, VEGF induces the formation ofVEGFR-PDGFRbcomplexes in pericytes, which impede PDGFRbmediated adherence of ECs to pericytes. Finally, the perivascular basement membrane (BM) is also structurally abnormal in tumors—excessively thin or absent in certain regions and abnormally thick in others. |
回复此楼» 猜你喜欢
依托企业入选了国家启明计划青年人才。有无高校可以引进的。
已经有9人回复
-
有时候真觉得大城市人没有县城人甚至个体户幸福
已经有11人回复
-
表哥与省会女结婚，父母去帮带孩子被省会女气回家生重病了
已经有7人回复
-
同年申请2项不同项目，第1个项目里不写第2个项目的信息，可以吗
已经有8人回复
-
依托企业入选了国家启明计划青年人才。有无高校可以引进的。
已经有10人回复
-
天津大学招2026.09的博士生，欢迎大家推荐交流（博导是本人）
已经有9人回复
-
有院领导为了换新车，用横向课题经费买了俩车
已经有10人回复
-
AI 太可怕了，写基金时，提出想法，直接生成的文字比自己想得深远，还有科学性
已经有6人回复