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cainiaodui新虫 (小有名气)
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| Movement of molecules across vessel walls occurs by diffusion and convection. Diffusion is governed by concentration gradients across the vessel wall, whereas convection is governed by pressure gradients. To test whether the pressure gradient across the vascular wall improves the penetration of large molecules, we injected fluorescently-labeled BSA i.v. into MCaIV-tumor-bearing mice and observed the pattern of BSA extravasation. We also identified functional blood vessels using biotinylated lectin. Quantitative analysis confirmed that DC101 produced a significantly deeper penetration of BSA molecules into the tumor |
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