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文献introduction没怎么看懂求大神指教，，我是学化学的里面生物的很不懂 求赐教
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The molecules that have been studied in tissue engineering of bones and cardiosphere derived stem-cell therapy are hydrogen peroxide, sometimes combinedwith catalase,and in the context of pancreatic islet regeneration inorganic peroxides such as calcium peroxide that eventually produce hydrogen peroxide.Soaking of biocompatible polymers such as poly(lactic-co-glycolic acid) (PLGA)has led to promising results, showcasing the possibility to rescue hypoxic tissue and, as a consequence, decrease necrosis of tissue over multiple days in a naked mouse skin flap model. However, an issue can be the cytotoxicity of the H2O2/catalase mixture or, more generally, uncontrolled release of oxygen and ions such as Ca2+. On this account, endoperoxides incorporated into small organic molecules are interesting alternatives owing to their ability to release oxygen in a retro-Diels−Alder reaction following first order kinetics. The reaction rate can likely be controlled by the substitution pattern on the scaffold and does not rely on the presence of enzymes or other triggers. Moreover, these scaffolds could be attached covalently to a solid support, opening up the possibility to synthesize oxygen-releasing polymers with defined rates of oxygen release and without soluble byproducts, such as calcium ions. Systems that have been shown to reversibly incorporate oxygen are derived from polyaromatic hydro- carbons, for example, naphthalene and anthracene or different 2-pyridones. The latter provide a scaffold that allows straightforward generation of interesting substitution patterns, while their polar nature should enhance solubility in watercompared with, for example, anthracene-derived endoper- oxides. Thus, the controlled release of oxygen from substituted 2-pyridone-derived endoperoxides in an aqueous environment followed by subsequent quenching of initially formed 1O2 to 3O2, for example, by solvent deactivation potentially provides a new strategy to rescue anoxic tissue from necrosis. |
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| 骨组织工程和心肌球来源干细胞治疗组织工程中研究的分子为过氧化氢，有时为过氧化氢加过氧化氢酶。胰岛内再生性无机过氧化物如过氧化钙，最终产生过氧化氢。生物相容的聚合物如聚乳酸一羟基乙酸共聚物(PLGA)的植入结果喜人，展示了保全缺氧组织的可能，并且因此减少裸鼠皮瓣移植模型小鼠的组织坏死，皮瓣好多天不会坏死。然而，问题可能出在H2O2/过氧化氢酶混合物的细胞毒性，或更普遍的是，不受控制的氧和离子如Ca2+的释放。因为这个原因，掺入有机小分子的内过氧化物，由于他们在逆狄尔斯–阿尔德反应中按一级动力学释放氧气，这种内过氧化物是一种让人感兴趣的替代方案。反应速率有可能通过取代有序重叠的反应模式控制，并且不依赖于酶或其它触发剂。此外，这些有序重叠组群可以共价连接到固体支持物上，开辟了以明确的氧释放速率合成释放氧的聚合物，并且没有不溶性的副产物，如钙离子。已经表现可逆性结合氧的系统是从聚芳族烃衍生而来，例如，萘和蒽的或不同2 - 吡啶酮。2 - 吡啶酮提供的有序重叠组群，允许让人感兴趣的直接生成取代模式，而它们的极性性质，与蒽衍生的内过氧化物相比，在水中的溶解度应该提高了。水环境中被取代的2 - 吡啶酮衍生的内过氧化物 的可控性氧释放，随后进行后期淬灭，淬灭早期形成的1O2到3O2，例如，通过溶剂失活；因此极大地提供了一种全新的办法来保全缺氧组织不坏死。 |
4楼2014-05-02 02:09:49