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Chemical Reviews最新综述：荧光纳米材料及其相关体系的化学，生物与医药
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Chemistry, Biology, and Medicine of Fluorescent Nanomaterials and Related Systems: New Insights into Biosensing, Bioimaging, Genomics, Diagnostics, and Therapy 共49页 引文844篇 Jun Yao,† Mei Yang,† and Yixiang Duan* ,†,‡ †Research Center of Analytical Instrumentation, Analytical and Testing Center, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China ‡Research Center of Analytical Instrumentation, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610064, China Corresponding Author * Phone: +86-28-85418180. Fax: +86-28-85412316. E-mail:yduan@scu.edu.cn. The combination of fl uorescence and nanomaterials has developed into an emerging research area: fl uorescent nanoparticles. Nanomaterials are at the leading edge of the rapidly developing fi eld of nanotechnology and have attracted increasing interest for bioanalytical labeling applications in recent years. Their unique size-dependent properties make these materials superior and indispensable in many areas of human activity. Meanwhile, fl uorescence-based detection is the most common method utilized in biosensing because of its high sensitivity, simplicity, and diversity. The emerging development and innovation of luminescent nanoparticles (NPs) with unique optical properties, yet complicated surface chemistry, paves new roads for fl uorescence imaging and sensing as well as for in vitro and in vivo labeling in cells, tissues, and organisms. As a result, this approach is widely employed in various areas of biology and medicine, including proteomic and genomic studies, disease diagnostics, pharmaceutical screening, drug delivery, assembled molecular control, protein puri fi cation, biological therapeutics, and medical imaging (such as in vivo imaging, sensing in cancer research, and selective tumor targeting). Speci fi cally, we selected size- and shape-dependent photoluminescence (PL) of quantum dots (QDs) as well as plasmon of metal NPs and discuss their biological applications.This review summarizes the applications of di ff erent NPs (including QDs, rare earth doped NPs, gold NPs, or silica NPs) in biosensing and imaging using detection techniques such as fl uorescence, fl uorescence resonance energy transfer (FRET), fl uorescence lifetime measurement, and multiphoton microscopy. Herein, we try to illustrate the main limitations and future directions of NPs in these areas of study. CONTENTS 1. Overview A 2. Introduction B 3. Theory and Background C 4. Several Classes of Signi fi cant Nanoparticles D 4.1. Quantum Dots D 4.2. Noble Metal Nanoparticles E 4.3. Silicon Nanomaterials F 4.4. Upconversion Nanomaterials F 4.5. Multifunctional Nanoparticles F 5. Bioanalysis Applications H 5.1. Biological Sensing Technology H 5.1.1. FRET-Based Biosensors H 5.1.2. Photoinduced Electron Transfer and Charge Transfer J 5.1.3. Metal-Enhanced Fluorescence L 5.1.4. Multiplexed Assays M 5.2. Genomics N 5.2.1. Aptamer N 5.2.2. Single Nucleotide Polymorphism O 5.2.3. RNA Interference Q 5.2.4. Fluorescence in Situ Hybridization R 6. Biomedical Applications S 6.1. Pathogen Detection S 6.2. Antibacterial Activity T 6.3. Immunoassay U 6.4. Drug Delivery V 6.5. Protein Corona W 6.6. Biotherapeutics Y 6.6.1. Photodynamic Therapy Y 6.6.2. Hyperthermia Y 7. Bioimaging AA 7.1. Near-Infrared Fluorescence Imaging AA 7.2. Quantum Dots for Bioimaging AB 7.3. Upconversion Nanoparticles for Bioimaging AC 7.4. Silica Nanoparticles for Bioimaging AD 7.5. Carbon Nanomaterials for Bioimaging AE 7.6. Multifunctional Nanoparticles for Bioimaging AF 8. Other Fluorescence-Based Applications AF 8.1. Fluorescence Lifetime Imaging Microscopy AF 8.2. Fluorescence Polarization Correlation Measurement AG 9. Conclusion and Perspectives AH Author Information AI Corresponding Author AI Notes AI Biographies AI Acknowledgments AJ Abbreviations AJ References AK  |
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