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cainiaodui新虫 (小有名气)
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Given these findings, coupling agents that block the VEGF pathway with agents targeting the Notch pathway may result in enhanced treatment efficacy. Combined therapy may therefore overcome the issue of tumor escape that is associated with single-agent treatments. Evidence of this benefit was demonstrated when anti-DLL4 antibody was combined with VEGF inhibition in human lung carcinoma and mouse leukemia tumor models. In both studies, combined therapy resulted in enhanced tumor growth inhibition as compared to either monotherapy.It has also been shown that human sarcoma xenograft tumors in mice that are unresponsive to VEGF inhibition are instead responsive to DLL4 blocking antibody.These data further exemplify the crosstalk between VEGF and the Notch signaling pathway. Clearly, the field of Notch pathway inhibitors is a new and exciting area in cancer research, and additional study of their use both alone and in combination with chemotherapy or other biological agents should be explored. |
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yifeng1206
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2楼2014-04-26 21:06:07
RXMCDM
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3楼2014-04-26 21:22:00
RXMCDM
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cainiaodui: 金币+10, 翻译EPI+1 2014-05-01 10:39:17
cainiaodui: 金币+10, 翻译EPI+1 2014-05-01 10:39:17
| 考虑到这些研究结果，偶联剂阻断VEGF通路同时用靶向试剂靶向Notch通路可以增强治疗效果。联合治疗因此可克服与单一药物治疗有关的肿瘤逃逸问题。 在人肺癌和白血病小鼠肿瘤模型抗DLL4抗体联合VEGF抑制显示了如此的治疗效果。这两项研究中，联合治疗肿瘤生长抑制作用与但种药物治疗相比，抑制作用增强。而且，还已经表明，人类肉瘤异种移植到小鼠的肿瘤对血管内皮生长因子抑制无反应性，但对DLL4封闭抗体有反应。这些数据进一步说明VEGF信号通路和Notch信号信号通路之间的串扰/相互作用。显然， Notch通路抑制剂是癌症研究中一个全新的和令人激动的领域，应用两种方法单独或两种方法与化疗或其他生物试剂联合使用应该进行进一步探讨、研究。 |
4楼2014-04-30 21:20:03
