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In the embryo, new vessels form de novo via the assembly of mesoderm-derived endothelial precursors (angioblasts) that
differentiate into a primitive vascular labyrinth (vasculogenesis). Subsequent vessel sprouting (angiogenesis) creates a network that remodels into
arteries and veins. Recruitment of pericytes and vascular smooth muscle cells that enwrap nascent EC tubules provides stability and regulates perfusion (arteriogenesis) . In the adult, vessels are quiescent and rarely form new branches. However, ECs retain high plasticity to sense and respond to angiogenic signals.
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cainiaodui: 金币+5, 翻译EPI+1 2014-05-01 08:36:15
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