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| Primarily, the process of angiogenesis involves stimulation of endothelial cells that line the luminal surface of the blood vessel.Endothelial cells release proteases (e.g., matrix metalloproteinases), which breakdown the surrounding basal extracellular membrane. Endothelial cells penetrate through the extracel­lular membrane and enter the underlying tissue. This sprouting process is spearheaded by lead­ing endothelial tip cells that migrate along the chemotaxic gradient towards the source of the angiogenic stimuli . |
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2楼2014-04-26 19:11:31