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Angew. Chem. Int. Ed.热点综述:智能自组装杂化水凝胶生物材料
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本综述着眼于基于生物识别的自组装杂化大分子的功能化生物材料 Smart Self-Assembled Hybrid Hydrogel Biomaterials Jindrich Kopecek* and Jiyuan Yang Department of Pharmaceutics and Pharmaceutical Chemistry, Department of Bioengineering, University of Utah Salt Lake City, Utah 84112 (USA) E-mail: jindrich.kopecek@utah.edu Hybrid biomaterials are systems created from components of at least two distinct classes of molecules, for example, synthetic macromolecules and proteins or peptide domains. The synergistic combination of two types of structures may produce new materials that possess unprecedented levels of structural organization and novel properties. This Review focuses on biorecognition-driven self-assembly of hybrid macromolecules into functional hydrogel biomaterials. First, basic rules that govern the secondary structure of peptides are discussed, and then approaches to the specific design of hybrid systems with tailor-made properties are evaluated, followed by a discussion on the similarity of design principles of biomaterials and macromolecular therapeutics. Finally, the future of the field is briefly outlined. |
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2014-04-25 16:37
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