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[资源] Adv. Funct. Mater. 最新专题文章：Click Chemistry in Materials Science

点击化学Click chemistry是2001年美国诺贝尔化学奖获得者K. Barry Sharpless等提出的一系列反应，其核心是开辟一整套以含杂原子链接单元C—X—C为基础的组合化学新方法，用少量简单可靠和高选择性的化学转变来获得更广泛的分子多样性。虽然应用时间不长，但是点击化学已经成为材料科学中最经典的范例性反应之一。由于“点击反应”具有的高效和高控制性，在化学合成领域掀起了一场风暴。所谓可靠的化学反应意指这些反应能够产生高立体选择性的产物，且其副产物无毒而对氧气和水不敏感，这意味着产物具有相当高的稳定性。此专题文章系统全面的介绍了其在材料科学中的应用。

Click Chemistry in Materials Science
Weixian Xi, Timothy F. Scott, Christopher J. Kloxin, and Christopher N. Bowman*
DOI: 10.1002/adfm.201302847
W. Xi, Dr. C. N. Bowman
Department of Chemical and Biological Engineering
Materials Science and Engineering Program
University of Colorado
Boulder  , Colorado 80309–0596  , USA
E-mail: christopher.bowman@colorado.edu
Dr. T. F. Scott
Department of Chemical Engineering
University of Michigan
Ann Arbor  , Michigan 48109–2136  , USA
Dr. C. J. Kloxin
Department of Materials Science & Engineering
150 Academy Street,    Newark, Delaware 19716  , USA
C. J. Kloxin
Department of Chemical & Biomolecular Engineering
University of Delaware
150 Academy Street  , Newark, Delaware 19716  , USA

The marriage between click chemistry and materials science is one  that  had  been  destined  to  occur  for  many  years.  Perhaps more  than  in  any  other  ﬁeld,  the  goal  of  materials  scientists, engineers, and manufacturers has been to achieve performance and a set of desired characteristics in the ﬁnal material and/or device in as simple and effective a manner as possible. These performance targets include speciﬁ cations on mechanical and physical behavior, such as toughness, modulus, glass transition temperature,  refractive  index,  and  clarity,  as  well  as  chemical attributes  such  as  solvent (in)compatibility,  surface  energy, chemical  functionality,  and  biocompatibility.  Process  considerations such as the raw materials, process safety, solvent, and environmental  considerations  are  also  of  great  importance. This focus on material properties and performance aligns well with the goals espoused by Sharpless and coworkers when they ﬁ rst introduced the “click” chemistry paradigm, wherein they argued that the focus of chemical process selection  should  be  directed  towards  the identiﬁ cation,  optimization,  and  simpliﬁcation  of  an  overall  process.Thus,  this process  identiﬁcation  includes  the  selection  of  initial  target  molecules,  starting materials,  and  the  reactions  used  to  synthesize  them,  ultimately  leading  to  the straightforward generation of a compound with  the  desired  properties  via  a  simple, robust process.

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